NVP-BEZ235, a dual PI3K/mTOR inhibitor, induces cell death through alternate routes in prostate cancer cells depending on the PTEN genotype.

Hong, Seung-Woo; Shin, Jae-Sik; Moon, Jai-Hee; Kim, Ye-Seul; Lee, Jooyoung; Choi, Eun Kyoung; Ha, Seung-Hee; Lee, Dae Hee; Chung, Ha Na; Kim, Jeong Eun; Kim, Kyu-Pyo; Hong, Yong Sang; Lee, Jae-Lyun; Lee, Wang-Jae; Choi, Eun Kyung; Lee, Jung Shin; Jin, Dong-Hoon; Kim, Tae Won

Hong, Seung-Woo; Shin, Jae-Sik; Moon, Jai-Hee; Kim, Ye-Seul; Lee, Jooyoung; Choi, Eun Kyoung; Ha, Seung-Hee; Lee, Dae Hee; Chung, Ha Na; Kim, Jeong Eun; Kim, Kyu-Pyo; Hong, Yong Sang; Lee, Jae-Lyun; Lee, Wang-Jae; Choi, Eun Kyung; Lee, Jung Shin; Jin, Dong-Hoon; Kim, Tae Won.

Affiliation

Hong SW; Innovative Cancer Research, Asan Institute for Life Science, University of Ulsan College of Medicine, Asan Medical Center, 86 Asanbyeongwon-gil, Songpa-gu, Seoul, 138-736, Republic of Korea.

Apoptosis ; 19(5): 895-904, 2014 May.

Article in En | MEDLINE | ID: mdl-24652480

Subject(s)

Antineoplastic Agents/pharmacology; Apoptosis/drug effects; Imidazoles/pharmacology; PTEN Phosphohydrolase/metabolism; Phosphoinositide-3 Kinase Inhibitors; Prostatic Neoplasms/pathology; Quinolines/pharmacology; TOR Serine-Threonine Kinases/antagonists & inhibitors; Cell Line, Tumor/drug effects; Drug Resistance, Neoplasm/genetics; Genotype; Humans; Male; PTEN Phosphohydrolase/genetics; Phosphatidylinositol 3-Kinases/metabolism; Prostatic Neoplasms/metabolism; TOR Serine-Threonine Kinases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Quinolines / Apoptosis / PTEN Phosphohydrolase / TOR Serine-Threonine Kinases / Phosphoinositide-3 Kinase Inhibitors / Imidazoles / Antineoplastic Agents Limits: Humans / Male Language: En Journal: Apoptosis Year: 2014 Type: Article

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