Implications of the E-selectin S128R mutation for drug discovery.

Preston, Roland C; Rabbani, Said; Binder, Florian P C; Moes, Suzette; Magnani, John L; Ernst, Beat

Preston, Roland C; Rabbani, Said; Binder, Florian P C; Moes, Suzette; Magnani, John L; Ernst, Beat.

Affiliation

Preston RC; Institute of Molecular Pharmacy, Pharmacenter.
Rabbani S; Institute of Molecular Pharmacy, Pharmacenter.
Binder FP; Institute of Molecular Pharmacy, Pharmacenter.
Moes S; Department of Biochemistry, Biocenter, University of Basel, Klingelbergstrasse 50, CH-4056 Basel, Switzerland.
Magnani JL; GlycoMimetics, Inc., Gaithersburg, MD 20879, USA.
Ernst B; Institute of Molecular Pharmacy, Pharmacenter beat.ernst@unibas.ch.

Glycobiology ; 24(7): 592-601, 2014 Jul.

Article in En | MEDLINE | ID: mdl-24688092

Subject(s)

Drug Discovery/methods; E-Selectin/metabolism; Mutation, Missense; Amino Sugars/pharmacology; Animals; CHO Cells; Cell Line, Tumor; Cricetinae; Cricetulus; E-Selectin/genetics; Fetuins/pharmacology; Heparin/pharmacology; Humans; Ligands; Microarray Analysis; Oligosaccharides/pharmacology; Protein Binding; Sialyl Lewis X Antigen

Key words

E-selectin; S128R; sLex mimic; selectin antagonists; single-nucleotide polymorphism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: E-Selectin / Mutation, Missense / Drug Discovery Limits: Animals / Humans Language: En Journal: Glycobiology Journal subject: BIOQUIMICA Year: 2014 Type: Article

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