Gene expression signatures in motor neurone disease fibroblasts reveal dysregulation of metabolism, hypoxia-response and RNA processing functions.

Raman, Rohini; Allen, Scott P; Goodall, Emily F; Kramer, Shelley; Ponger, Lize-Linde; Heath, Paul R; Milo, Marta; Hollinger, Hannah C; Walsh, Theresa; Highley, J Robin; Olpin, Simon; McDermott, Christopher J; Shaw, Pamela J; Kirby, Janine

Raman, Rohini; Allen, Scott P; Goodall, Emily F; Kramer, Shelley; Ponger, Lize-Linde; Heath, Paul R; Milo, Marta; Hollinger, Hannah C; Walsh, Theresa; Highley, J Robin; Olpin, Simon; McDermott, Christopher J; Shaw, Pamela J; Kirby, Janine.

Affiliation

Raman R; Sheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, Sheffield, UK.

Neuropathol Appl Neurobiol ; 41(2): 201-26, 2015 Feb.

Article in En | MEDLINE | ID: mdl-24750211

Subject(s)

Fibroblasts/metabolism; Fibroblasts/pathology; Gene Expression Profiling/methods; Motor Neuron Disease/genetics; Transcriptome; Adult; Aged; Cell Hypoxia/physiology; Cells, Cultured; Female; Humans; Immunoblotting; Male; MicroRNAs/analysis; Middle Aged; Motor Neuron Disease/metabolism; Motor Neuron Disease/pathology; Oligonucleotide Array Sequence Analysis/methods

Key words

amyotrophic lateral sclerosis; cell models; fibroblasts; hypoxia response; microRNA; microarray; primary lateral sclerosis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Motor Neuron Disease / Gene Expression Profiling / Transcriptome / Fibroblasts Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Neuropathol Appl Neurobiol Year: 2015 Type: Article Affiliation country: United kingdom

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