Insufficient interleukin-12 signalling favours differentiation of human CD4(+) and CD8(+) T cells into GATA-3(+) and GATA-3(+) T-bet(+) subsets in humanized mice.

Billerbeck, Eva; Labitt, Rachael N; Vega, Kevin; Frias-Staheli, Natalia; Dorner, Marcus; Xiao, Jing W; Rice, Charles M; Ploss, Alexander

Billerbeck, Eva; Labitt, Rachael N; Vega, Kevin; Frias-Staheli, Natalia; Dorner, Marcus; Xiao, Jing W; Rice, Charles M; Ploss, Alexander.

Affiliation

Billerbeck E; Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University, New York, NY, USA.

Immunology ; 143(2): 202-18, 2014 Oct.

Article in En | MEDLINE | ID: mdl-24766459

Subject(s)

CD4-Positive T-Lymphocytes/metabolism; CD8-Positive T-Lymphocytes/metabolism; Cell Differentiation; GATA3 Transcription Factor/metabolism; Hematopoietic Stem Cell Transplantation; Interleukin-12/metabolism; Signal Transduction; T-Box Domain Proteins/metabolism; T-Lymphocyte Subsets/metabolism; Adenoviridae/pathogenicity; Animals; CD4-Positive T-Lymphocytes/drug effects; CD4-Positive T-Lymphocytes/immunology; CD4-Positive T-Lymphocytes/virology; CD8-Positive T-Lymphocytes/drug effects; CD8-Positive T-Lymphocytes/immunology; CD8-Positive T-Lymphocytes/virology; Cell Lineage; Cells, Cultured; Dendritic Cells/immunology; Dendritic Cells/metabolism; Host-Pathogen Interactions; Humans; Injections, Intraperitoneal; Interferon-gamma/metabolism; Interleukin-12/administration & dosage; Interleukin-4/metabolism; Kinetics; Liver/immunology; Liver/metabolism; Liver/virology; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, SCID; Mice, Transgenic; Phenotype; Signal Transduction/drug effects; T-Lymphocyte Subsets/drug effects; T-Lymphocyte Subsets/immunology; T-Lymphocyte Subsets/virology; Transplantation, Heterologous; Viral Load

Key words

T-cell plasticity; humanized mice; interleukin-12

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CD4-Positive T-Lymphocytes / Signal Transduction / Cell Differentiation / T-Lymphocyte Subsets / Interleukin-12 / Hematopoietic Stem Cell Transplantation / CD8-Positive T-Lymphocytes / T-Box Domain Proteins / GATA3 Transcription Factor Language: En Journal: Immunology Year: 2014 Type: Article Affiliation country: United States

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