The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn disease.

Mohanan, Vishnu; Grimes, Catherine Leimkuhler

Mohanan, Vishnu; Grimes, Catherine Leimkuhler.

Affiliation

Mohanan V; From the Departments of Biological Sciences and.
Grimes CL; From the Departments of Biological Sciences and Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716 cgrimes@udel.edu.

J Biol Chem ; 289(27): 18987-98, 2014 Jul 04.

Article in En | MEDLINE | ID: mdl-24790089

Subject(s)

Crohn Disease/metabolism; HSP70 Heat-Shock Proteins/metabolism; Nod2 Signaling Adaptor Protein/metabolism; Acetylmuramyl-Alanyl-Isoglutamine/pharmacology; Animals; Cell Wall/metabolism; Crohn Disease/genetics; Crohn Disease/microbiology; Crohn Disease/pathology; Gene Expression Regulation/drug effects; HCT116 Cells; HEK293 Cells; Half-Life; Humans; Mutation; NF-kappa B/metabolism; Nod2 Signaling Adaptor Protein/chemistry; Protein Binding; Protein Stability/drug effects; Signal Transduction/drug effects; Tetracycline/pharmacology

Key words

Cell Wall; HSP70; Innate Immunity; Muramyl Dipeptide; NF-κB; NOD2; Nod-like Receptor; Peptidoglycan; Signal Transduction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Crohn Disease / HSP70 Heat-Shock Proteins / Nod2 Signaling Adaptor Protein Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2014 Type: Article

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