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DNA-scaffolded multivalent ligands to modulate cell function.
Zhang, Zhiqing; Eckert, Mark A; Ali, M Monsur; Liu, Linan; Kang, Dong-Ku; Chang, Elizabeth; Pone, Egest J; Sender, Leonard S; Fruman, David A; Zhao, Weian.
Affiliation
  • Zhang Z; State Key Laboratory of Heavy Oil Processing, College of Science, China University of Petroleum, 66 Changjiang (West) Rd, Huangdao, Qingdao, 266580 (P. R. China); Department of Pharmaceutical Sciences, Department of Biomedical Engineering, Sue and Bill Gross Stem Cell Research Center and Chao Family Comprehensive Cancer Center, and Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, 845 Health Sciences Road, Irvine, CA 92697 (USA) http://faculty.
Chembiochem ; 15(9): 1268-73, 2014 Jun 16.
Article in En | MEDLINE | ID: mdl-24803415
ABSTRACT
We report a simple, versatile, multivalent ligand system that is capable of specifically and efficiently modulating cell-surface receptor clustering and function. The multivalent ligand is made of a polymeric DNA scaffold decorated with biorecognition ligands (i.e., antibodies) to interrogate and modulate cell receptor signaling and function. Using CD20 clustering-mediated apoptosis in B-cell cancer cells as a model system, we demonstrated that our multivalent ligand is significantly more effective at inducing apoptosis of target cancer cells than its monovalent counterpart. This multivalent DNA material approach represents a new chemical biology tool to interrogate cell receptor signaling and functions and to potentially manipulate such functions for the development of therapeutics.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA / Antibodies / Neoplasms Limits: Humans Language: En Journal: Chembiochem Journal subject: BIOQUIMICA Year: 2014 Type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA / Antibodies / Neoplasms Limits: Humans Language: En Journal: Chembiochem Journal subject: BIOQUIMICA Year: 2014 Type: Article