Population pharmacokinetics of imipenem in critically ill patients with suspected ventilator-associated pneumonia and evaluation of dosage regimens.

Couffignal, Camille; Pajot, Olivier; Laouénan, Cédric; Burdet, Charles; Foucrier, Arnaud; Wolff, Michel; Armand-Lefevre, Laurence; Mentré, France; Massias, Laurent

Couffignal, Camille; Pajot, Olivier; Laouénan, Cédric; Burdet, Charles; Foucrier, Arnaud; Wolff, Michel; Armand-Lefevre, Laurence; Mentré, France; Massias, Laurent.

Affiliation

Couffignal C; AP-HP, Hop Bichat, Biostatistics Department, Paris, France; IAME, UMR 1137, Univ Paris Diderot, Sorbonne Paris Cité, F-75018, Paris, France; IAME, UMR 1137, INSERM, F-75018, Paris, France.

Br J Clin Pharmacol ; 78(5): 1022-34, 2014 Nov.

Article in En | MEDLINE | ID: mdl-24903189

Subject(s)

Anti-Bacterial Agents/pharmacokinetics; Imipenem/pharmacokinetics; Pneumonia, Ventilator-Associated/drug therapy; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents/administration & dosage; Anti-Bacterial Agents/blood; Anti-Bacterial Agents/therapeutic use; Critical Illness; Dose-Response Relationship, Drug; Female; Gram-Negative Bacteria/drug effects; Humans; Imipenem/administration & dosage; Imipenem/blood; Imipenem/therapeutic use; Infusions, Intravenous; Male; Middle Aged; Models, Biological; Models, Statistical; Monte Carlo Method; Pneumonia, Ventilator-Associated/blood; Pneumonia, Ventilator-Associated/metabolism; Pneumonia, Ventilator-Associated/microbiology; Prospective Studies

Key words

critical care; imipenem; population pharmacokinetics; ventilator-associated pneumonia

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Imipenem / Pneumonia, Ventilator-Associated / Anti-Bacterial Agents Type of study: Clinical_trials / Health_economic_evaluation / Observational_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Br J Clin Pharmacol Year: 2014 Type: Article Affiliation country: France

Fulltext

XML

PubMed Links

Search on Google