Urokinase stimulates production of matrix metalloproteinase-9 in fibroblasts with involvement of reactive oxygen species.
Bull Exp Biol Med
; 157(1): 18-21, 2014 May.
Article
in En
| MEDLINE
| ID: mdl-24906961
ABSTRACT
In cultured fibroblasts, urokinase stimulated expression of MMP-9 and generation of ROS, while antioxidant ebselen abolished the stimulating effect of urokinase on MMP-9 expression. sTNF-α produced similar and more pronounced stimulating effect. The data showed that urokinase could regulate MMP-9 expression via ROS generation in fibroblasts, which can play an important role in stimulation of their migration and development of constrictor (negative) vascular remodeling due to thickening of the adventitia.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Urokinase-Type Plasminogen Activator
/
Reactive Oxygen Species
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Matrix Metalloproteinase 9
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Fibroblasts
Limits:
Animals
Language:
En
Journal:
Bull Exp Biol Med
Year:
2014
Type:
Article
Affiliation country:
RUSSIA