[Metabolic changes in abnormal savda patients with different types of tumor: a clinical observation].
Zhongguo Zhong Xi Yi Jie He Za Zhi
; 34(5): 549-53, 2014 May.
Article
in Zh
| MEDLINE
| ID: mdl-24941842
ABSTRACT
OBJECTIVE:
To explore in vivo metabolic changes in abnormal savda patients with different types of tumor.METHODS:
A total of 142 abnormal savda patients with common cancer types were enrolled in this study, and 50 healthy volunteers were recruited as the control group. For each sample, the H Nuclear Magnetic Resonance (NMR) based metabonomic analysis was performed. The free attenuation signal was computed subsection integral. Data obtained were analyzed by the Orthogonal Partial Least-Squares Discriminant Analysis (OPLS-DA).RESULTS:
Compared with the control group, leucine, isoleucine, valine, histidine, phenylalanine, tyrosine, alanine, creatine, lactic acid, inositol, alpha-and beta-glucose, unsaturated lipids, very low density lipoprotein (VLDL) significantly decreased (P <0.05), while glycoprotein and carnitine significantly increased (P <0. 05) in the abnormal Savda group.CONCLUSION:
Abnormal savda patients with different types of tumor had similar metabonomics changes.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Metabolome
/
Neoplasms
Type of study:
Observational_studies
Limits:
Humans
Language:
Zh
Journal:
Zhongguo Zhong Xi Yi Jie He Za Zhi
Journal subject:
TERAPIAS COMPLEMENTARES
Year:
2014
Type:
Article