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Sequencing-based approach identified three new susceptibility loci for psoriasis.
Sheng, Yujun; Jin, Xin; Xu, Jinhua; Gao, Jinping; Du, Xiaoqing; Duan, Dawei; Li, Bing; Zhao, Jinhua; Zhan, Wenying; Tang, Huayang; Tang, Xianfa; Li, Yang; Cheng, Hui; Zuo, Xianbo; Mei, Junpu; Zhou, Fusheng; Liang, Bo; Chen, Gang; Shen, Changbing; Cui, Hongzhou; Zhang, Xiaoguang; Zhang, Change; Wang, Wenjun; Zheng, Xiaodong; Fan, Xing; Wang, Zaixing; Xiao, Fengli; Cui, Yong; Li, Yingrui; Wang, Jun; Yang, Sen; Xu, Lei; Sun, Liangdan; Zhang, Xuejun.
Affiliation
  • Sheng Y; 1] Department of Dermatology, No. 2 Hospital, Anhui Medical University, Hefei, Anhui 230601, China [2] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [3] Department of Dermatology, Huashan Hospital of Fudan University, Sha
  • Jin X; 1] BGI-Shenzhen, Shenzhen 518083, China [2] School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 518055, China [3].
  • Xu J; 1] Department of Dermatology, Huashan Hospital of Fudan University, Shanghai 200040, China [2].
  • Gao J; 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of
  • Du X; 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of
  • Duan D; 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of
  • Li B; 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of
  • Zhao J; 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of
  • Zhan W; 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of
  • Tang H; 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of
  • Tang X; 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of
  • Li Y; 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of
  • Cheng H; 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of
  • Zuo X; 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of
  • Mei J; BGI-Shenzhen, Shenzhen 518083, China.
  • Zhou F; 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of
  • Liang B; 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of
  • Chen G; 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of
  • Shen C; 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of
  • Cui H; 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of
  • Zhang X; 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of
  • Zhang C; 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of
  • Wang W; 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of
  • Zheng X; 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of
  • Fan X; 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of
  • Wang Z; 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of
  • Xiao F; 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of
  • Cui Y; 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of
  • Li Y; BGI-Shenzhen, Shenzhen 518083, China.
  • Wang J; 1] BGI-Shenzhen, Shenzhen 518083, China [2] Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen N, Denmark [3] Department of Biology, University of Copenhagen, DK-2200 Copenhagen N, Denmark.
  • Yang S; 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of
  • Xu L; Department of Computer Science and Engineering, Rm1028 Ho Sin-Hang Engineering Building, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China.
  • Sun L; 1] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [2] Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China [3] Key Laboratory of Dermatology, Anhui Medical University, Ministry of
  • Zhang X; 1] Department of Dermatology, No. 2 Hospital, Anhui Medical University, Hefei, Anhui 230601, China [2] Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China [3] Department of Dermatology, Huashan Hospital of Fudan University, Sha
Nat Commun ; 5: 4331, 2014 Jul 09.
Article in En | MEDLINE | ID: mdl-25006012
In a previous large-scale exome sequencing analysis for psoriasis, we discovered seven common and low-frequency missense variants within six genes with genome-wide significance. Here we describe an in-depth analysis of noncoding variants based on sequencing data (10,727 cases and 10,582 controls) with replication in an independent cohort of Han Chinese individuals consisting of 4,480 cases and 6,521 controls to identify additional psoriasis susceptibility loci. We confirmed four known psoriasis susceptibility loci (IL12B, IFIH1, ERAP1 and RNF114; 2.30 × 10(-20)≤P≤2.41 × 10(-7)) and identified three new susceptibility loci: 4q24 (NFKB1) at rs1020760 (P=2.19 × 10(-8)), 12p13.3 (CD27-LAG3) at rs758739 (P=4.08 × 10(-8)) and 17q12 (IKZF3) at rs10852936 (P=1.96 × 10(-8)). Two suggestive loci, 3p21.31 and 17q25, are also identified with P<1.00 × 10(-6). The results of this study increase the number of confirmed psoriasis risk loci and provide novel insight into the pathogenesis of psoriasis.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Psoriasis / Antigens, CD / Tumor Necrosis Factor Receptor Superfamily, Member 7 / Genetic Predisposition to Disease / Asian People / Ikaros Transcription Factor / NF-kappa B p50 Subunit Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2014 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Psoriasis / Antigens, CD / Tumor Necrosis Factor Receptor Superfamily, Member 7 / Genetic Predisposition to Disease / Asian People / Ikaros Transcription Factor / NF-kappa B p50 Subunit Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2014 Type: Article