Preparation of ibuprofen-loaded chitosan films for oral mucosal drug delivery using supercritical solution impregnation.

Tang, Chuan; Guan, Yi-Xin; Yao, Shan-Jing; Zhu, Zi-Qiang

Tang, Chuan; Guan, Yi-Xin; Yao, Shan-Jing; Zhu, Zi-Qiang.

Affiliation

Tang C; Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.
Guan YX; Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China. Electronic address: guanyx@zju.edu.cn.
Yao SJ; Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.
Zhu ZQ; Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.

Int J Pharm ; 473(1-2): 434-41, 2014 Oct 01.

Article in En | MEDLINE | ID: mdl-25079432

Subject(s)

Anti-Inflammatory Agents, Non-Steroidal/chemistry; Chitosan/chemistry; Drug Carriers/chemistry; Ibuprofen/chemistry; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage; Bacterial Load; Chitosan/administration & dosage; Drug Carriers/administration & dosage; Drug Compounding/methods; Female; Ibuprofen/administration & dosage; Mouth Mucosa/metabolism; Pseudomonas aeruginosa/drug effects; Pseudomonas aeruginosa/growth & development; Rabbits; Solutions; Staphylococcus aureus/drug effects; Staphylococcus aureus/growth & development

Key words

Ibuprofen; In vitro and ex vivo release; Mucoadhesive chitosan film; Oral mucosal drug delivery system; Supercritical solution impregnation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Carriers / Anti-Inflammatory Agents, Non-Steroidal / Ibuprofen / Chitosan Limits: Animals Language: En Journal: Int J Pharm Year: 2014 Type: Article Affiliation country: China

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