CXCR4antagonism as a therapeutic approach to prevent acute kidney injury.

Zuk, A; Gershenovich, M; Ivanova, Y; MacFarland, R T; Fricker, S P; Ledbetter, S

Zuk, A; Gershenovich, M; Ivanova, Y; MacFarland, R T; Fricker, S P; Ledbetter, S.

Affiliation

Zuk A; Tissue Protection and Repair Unit, Renal Science, Genzyme R&D Center, Framingham, Massachusetts; anna.zuk@genzyme.com.
Gershenovich M; Tissue Protection and Repair Unit, Renal Science, Genzyme R&D Center, Framingham, Massachusetts;
Ivanova Y; Tissue Protection and Repair Unit, Renal Science, Genzyme R&D Center, Framingham, Massachusetts;
MacFarland RT; Pharmacology and Preclinical Development, Genzyme R&D Center, Framingham, Massachusetts; and.
Fricker SP; Immune-Mediated Disease Research, Genzyme R&D Center, Framingham, Massachusetts.
Ledbetter S; Tissue Protection and Repair Unit, Renal Science, Genzyme R&D Center, Framingham, Massachusetts;

Am J Physiol Renal Physiol ; 307(7): F783-97, 2014 Oct 01.

Article in En | MEDLINE | ID: mdl-25080523

Subject(s)

Acute Kidney Injury/prevention & control; Heterocyclic Compounds/therapeutic use; Receptors, CXCR4/antagonists & inhibitors; Reperfusion Injury/prevention & control; Acute Kidney Injury/immunology; Animals; Benzylamines; Chemokine CXCL12/metabolism; Cyclams; Flow Cytometry; Hematopoietic Stem Cells/drug effects; Heterocyclic Compounds/pharmacokinetics; Kidney Function Tests; Leukocytes/drug effects; Male; Pyridines/pharmacology; Pyridines/therapeutic use; Rats, Sprague-Dawley; Rats, Wistar; Reperfusion Injury/immunology

Key words

chemokine; immune modulation; renal ischemia-reperfusion

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Reperfusion Injury / Receptors, CXCR4 / Acute Kidney Injury / Heterocyclic Compounds Type of study: Prognostic_studies Limits: Animals Language: En Journal: Am J Physiol Renal Physiol Journal subject: FISIOLOGIA / NEFROLOGIA Year: 2014 Type: Article

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