Oxysterols synergize with statins by inhibiting SREBP-2 in ovarian cancer cells.

Casella, Cinzia; Miller, Daniel H; Lynch, Kerry; Brodsky, Alexander S

Casella, Cinzia; Miller, Daniel H; Lynch, Kerry; Brodsky, Alexander S.

Affiliation

Casella C; Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02903, USA.
Miller DH; Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02903, USA.
Lynch K; Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02903, USA.
Brodsky AS; Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02903, USA; Center for Computational Molecular Biology, Brown University, 151 Waterman St., Providence, RI 02912, USA; Center for Genomics and Proteomics, Brown University, 70 Ship St., Providence, RI 0

Gynecol Oncol ; 135(2): 333-41, 2014 Nov.

Article in En | MEDLINE | ID: mdl-25134999

Subject(s)

Apoptosis/drug effects; Hydroxycholesterols/pharmacology; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Simvastatin/pharmacology; Sterol Regulatory Element Binding Protein 2/antagonists & inhibitors; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Survival/drug effects; Drug Synergism; Drug Therapy, Combination; Female; Humans; Signal Transduction

Key words

Cholesterol; Ovarian cancer; SREBPs; Statins

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Apoptosis / Neoplasms, Glandular and Epithelial / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Simvastatin / Sterol Regulatory Element Binding Protein 2 / Hydroxycholesterols Limits: Female / Humans Language: En Journal: Gynecol Oncol Year: 2014 Type: Article Affiliation country: United States

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