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Denosumab mimics the natural decoy receptor osteoprotegerin by interacting with its major binding site on RANKL.
Schieferdecker, Aneta; Voigt, Mareike; Riecken, Kristoffer; Braig, Friederike; Schinke, Thorsten; Loges, Sonja; Bokemeyer, Carsten; Fehse, Boris; Binder, Mascha.
Affiliation
  • Schieferdecker A; Department of Oncology and Hematology, BMT with section Pneumology, Hubertus Wald Tumorzentrum / UCCH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Voigt M; Department of Oncology and Hematology, BMT with section Pneumology, Hubertus Wald Tumorzentrum / UCCH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Riecken K; Research Department Cell and Gene Therapy, Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Braig F; Department of Oncology and Hematology, BMT with section Pneumology, Hubertus Wald Tumorzentrum / UCCH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Schinke T; Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Loges S; Department of Oncology and Hematology, BMT with section Pneumology, Hubertus Wald Tumorzentrum / UCCH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Institute for Tumor Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Bokemeyer C; Department of Oncology and Hematology, BMT with section Pneumology, Hubertus Wald Tumorzentrum / UCCH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Fehse B; Research Department Cell and Gene Therapy, Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Binder M; Department of Oncology and Hematology, BMT with section Pneumology, Hubertus Wald Tumorzentrum / UCCH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Oncotarget ; 5(16): 6647-53, 2014 Aug 30.
Article in En | MEDLINE | ID: mdl-25138051
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bone Neoplasms / RANK Ligand / Osteoprotegerin / Antibodies, Monoclonal, Humanized Type of study: Prognostic_studies Limits: Humans Language: En Journal: Oncotarget Year: 2014 Type: Article Affiliation country: Germany
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bone Neoplasms / RANK Ligand / Osteoprotegerin / Antibodies, Monoclonal, Humanized Type of study: Prognostic_studies Limits: Humans Language: En Journal: Oncotarget Year: 2014 Type: Article Affiliation country: Germany