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Age-dependent suppression of hippocampal epileptic afterdischarges by metabotropic glutamate receptor 5 antagonist MTEP.
Zavala-Tecuapetla, Cecilia; Kubová, Hana; Otáhal, Jakub; Tsenov, Grygoriy; Mares, Pavel.
Affiliation
  • Zavala-Tecuapetla C; Department of Developmental Epileptology, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague 4, Czech Republic.
  • Kubová H; Department of Developmental Epileptology, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague 4, Czech Republic.
  • Otáhal J; Department of Developmental Epileptology, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague 4, Czech Republic.
  • Tsenov G; Department of Developmental Epileptology, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague 4, Czech Republic.
  • Mares P; Department of Developmental Epileptology, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague 4, Czech Republic. Electronic address: maresp@biomed.cas.cz.
Pharmacol Rep ; 66(5): 927-30, 2014 Oct.
Article in En | MEDLINE | ID: mdl-25150003
ABSTRACT
Action of an antagonist of metabotropic glutamate receptors subtype 5 MTEP was studied in a model of complex partial seizures. Dorsal hippocampus of rat pups 12, 18 and 25 days old was stimulated six times with 10-min intervals. MTEP (20 or 40 mg/kg) was injected after the first afterdischarge and duration of afterdischarges was measured. MTEP exhibited marked anticonvulsant action in 12-day-old-rats, the similar effect in 18-day-old rats was observed only with the second stimulation. No anticonvulsant action was seen in 25-day-old animals. Our results may qualify antagonists of mGluR5 as potential antiepileptic drugs for some types of childhood epilepsies.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Thiazoles / Epilepsy, Complex Partial / Receptor, Metabotropic Glutamate 5 / Anticonvulsants Type of study: Prognostic_studies Limits: Animals Language: En Journal: Pharmacol Rep Journal subject: FARMACOLOGIA Year: 2014 Type: Article Affiliation country: Czech Republic
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Thiazoles / Epilepsy, Complex Partial / Receptor, Metabotropic Glutamate 5 / Anticonvulsants Type of study: Prognostic_studies Limits: Animals Language: En Journal: Pharmacol Rep Journal subject: FARMACOLOGIA Year: 2014 Type: Article Affiliation country: Czech Republic