A phase I trial of pantoprazole in combination with doxorubicin in patients with advanced solid tumors: evaluation of pharmacokinetics of both drugs and tissue penetration of doxorubicin.

Brana, Irene; Ocana, Alberto; Chen, Eric X; Razak, Albiruni R A; Haines, Christine; Lee, Carol; Douglas, Sarah; Wang, Lisa; Siu, Lillian L; Tannock, Ian F; Bedard, Philippe L

Brana, Irene; Ocana, Alberto; Chen, Eric X; Razak, Albiruni R A; Haines, Christine; Lee, Carol; Douglas, Sarah; Wang, Lisa; Siu, Lillian L; Tannock, Ian F; Bedard, Philippe L.

Affiliation

Brana I; Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Department of Medicine, University of Toronto, 610 University Avenue, M5G 2 M9, Toronto, ON, Canada.

Invest New Drugs ; 32(6): 1269-77, 2014 Dec.

Article in En | MEDLINE | ID: mdl-25213162

Subject(s)

Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Neoplasms/drug therapy; 2-Pyridinylmethylsulfinylbenzimidazoles/administration & dosage; 2-Pyridinylmethylsulfinylbenzimidazoles/adverse effects; 2-Pyridinylmethylsulfinylbenzimidazoles/pharmacokinetics; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols/adverse effects; Antineoplastic Combined Chemotherapy Protocols/pharmacokinetics; Doxorubicin/administration & dosage; Doxorubicin/adverse effects; Doxorubicin/pharmacokinetics; Female; Humans; Male; Middle Aged; Neoplasms/metabolism; Pantoprazole; Response Evaluation Criteria in Solid Tumors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antineoplastic Combined Chemotherapy Protocols / Neoplasms Type of study: Prognostic_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Invest New Drugs Year: 2014 Type: Article Affiliation country: Canada

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