DNA intercalating Ru(II) polypyridyl complexes as effective photosensitizers in photodynamic therapy.

Mari, Cristina; Pierroz, Vanessa; Rubbiani, Riccardo; Patra, Malay; Hess, Jeannine; Spingler, Bernhard; Oehninger, Luciano; Schur, Julia; Ott, Ingo; Salassa, Luca; Ferrari, Stefano; Gasser, Gilles

Mari, Cristina; Pierroz, Vanessa; Rubbiani, Riccardo; Patra, Malay; Hess, Jeannine; Spingler, Bernhard; Oehninger, Luciano; Schur, Julia; Ott, Ingo; Salassa, Luca; Ferrari, Stefano; Gasser, Gilles.

Affiliation

Mari C; Department of Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich (Switzerland), WWW: www.gassergroup.com.

Chemistry ; 20(44): 14421-36, 2014 Oct 27.

Article in En | MEDLINE | ID: mdl-25213439

Subject(s)

Coordination Complexes/chemistry; Coordination Complexes/pharmacology; Intercalating Agents/chemistry; Intercalating Agents/pharmacology; Photosensitizing Agents/chemistry; Photosensitizing Agents/pharmacology; Ruthenium/chemistry; 2,2'-Dipyridyl/chemistry; Coordination Complexes/chemical synthesis; Crystallography, X-Ray; DNA/drug effects; HeLa Cells; Humans; Intercalating Agents/chemical synthesis; Photochemical Processes; Photochemotherapy; Photosensitizing Agents/chemical synthesis

Key words

DNA binding; density functional calculations; fluorescence microscopy; photodynamic therapy; singlet oxygen

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ruthenium / Photosensitizing Agents / Coordination Complexes / Intercalating Agents Limits: Humans Language: En Journal: Chemistry Journal subject: QUIMICA Year: 2014 Type: Article

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