Complement C5a potentiates uric acid crystal-induced IL-1ß production.

An, Ling-Ling; Mehta, Payal; Xu, Linda; Turman, Sean; Reimer, Thornik; Naiman, Brian; Connor, Jane; Sanjuan, Miguel; Kolbeck, Roland; Fung, Michael

An, Ling-Ling; Mehta, Payal; Xu, Linda; Turman, Sean; Reimer, Thornik; Naiman, Brian; Connor, Jane; Sanjuan, Miguel; Kolbeck, Roland; Fung, Michael.

Affiliation

An LL; Department of Respiratory, Inflammation and Autoimmune Diseases, MedImmune, LLC, Gaithersburg, MD, USA.

Eur J Immunol ; 44(12): 3669-79, 2014 Dec.

Article in En | MEDLINE | ID: mdl-25229885

Subject(s)

Antioxidants/pharmacology; Calcium Signaling/drug effects; Complement C5a/immunology; Interleukin-1beta/immunology; Monocytes/immunology; Uric Acid/pharmacology; Antioxidants/adverse effects; Calcium/immunology; Calcium Signaling/immunology; Caspase 1/immunology; Female; Humans; Inflammasomes/immunology; Male; Monocytes/pathology; Potassium/immunology; Uric Acid/adverse effects

Key words

C5a; Gout; IL-1ß; Inflammasome; Priming; monosodium urate/;uric acid (MSU) crystal

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uric Acid / Monocytes / Complement C5a / Calcium Signaling / Interleukin-1beta / Antioxidants Type of study: Prognostic_studies Limits: Female / Humans / Male Language: En Journal: Eur J Immunol Year: 2014 Type: Article Affiliation country: United States

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