Role of calcium in membrane interactions by PI(4,5)P2-binding proteins.
Biochem Soc Trans
; 42(5): 1441-6, 2014 Oct.
Article
in En
| MEDLINE
| ID: mdl-25233429
ABSTRACT
Ca²âº and phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] are key agents in membrane-associated signalling events. Their temporal and spatial regulation is crucial for activation or recruitment of proteins in the plasma membrane. In fact, the interaction of several signalling proteins with PI(4,5)P2 has been shown to be tightly regulated and dependent on the presence of Ca²âº, with co-operative binding in some cases. In these proteins, PI(4,5)P2 and Ca²âº binding typically occurs at different binding sites. In addition, several PI(4,5)P2-binding proteins are known targets of calmodulin (CaM), which, depending on the presence of calcium, can compete with PI(4,5)P2 for protein interaction, translating Ca²âº transient microdomains into variations of PI(4,5)P2 lateral organization in time and space. The present review highlights different examples of calcium-dependent PI(4,5)P2-binding proteins and discusses the possible impact of this dual regulation on fine-tuning of protein activity by triggering target membrane binding in the presence of subtle changes in the levels of calcium or PI(4,5)P2.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Models, Molecular
/
Annexin A2
/
Phosphatidylinositol 4,5-Diphosphate
/
Calcium Signaling
/
Membrane Microdomains
/
Protein Kinase C-alpha
/
Synaptotagmin I
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Biochem Soc Trans
Year:
2014
Type:
Article
Affiliation country:
Portugal