Adenocarcinoma in situ of the uterine cervix--a systematic review.
Int J Gynecol Cancer
; 24(9): 1543-8, 2014 Nov.
Article
in En
| MEDLINE
| ID: mdl-25238167
ABSTRACT
OBJECTIVE:
This study aimed to review literature if therapeutic strategies in adenocarcinoma in situ of the cervix could lead to a more conservative approach.METHODS:
A review of the literature was conducted using a Medline search for articles published between 1966 and 2013.RESULTS:
Thirty-five studies showed that after a radical cone, 16.5% residual disease in the re-cone or uterus was found. After cone with positive margins, residual abnormalities were found in 49.3%. Thirty-seven studies showed 5% recurrence rate after conservative therapy (large loop excision transformation zone-cold knife conization. After conization with negative margins, the risk of recurrence was 3%.CONCLUSIONS:
Adenocarcinoma in situ is a relatively rare premalignant but increasingly frequent lesion of the cervix. Although there is a risk of relapse (3%) with a chance of malignancy (<1%), this risk is so small that conservative treatment with negative margins by large loop excision transformation zone or cold knife conization is justified and justifiable not only for women to have children.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carcinoma in Situ
/
Adenocarcinoma
/
Uterine Cervical Neoplasms
Type of study:
Diagnostic_studies
/
Prognostic_studies
/
Systematic_reviews
Limits:
Female
/
Humans
Language:
En
Journal:
Int J Gynecol Cancer
Journal subject:
GINECOLOGIA
/
NEOPLASIAS
Year:
2014
Type:
Article
Affiliation country:
Netherlands