Transgenic expression of human CD47 markedly increases engraftment in a murine model of pig-to-human hematopoietic cell transplantation.

Tena, A; Kurtz, J; Leonard, D A; Dobrinsky, J R; Terlouw, S L; Mtango, N; Verstegen, J; Germana, S; Mallard, C; Arn, J S; Sachs, D H; Hawley, R J

Tena, A; Kurtz, J; Leonard, D A; Dobrinsky, J R; Terlouw, S L; Mtango, N; Verstegen, J; Germana, S; Mallard, C; Arn, J S; Sachs, D H; Hawley, R J.

Affiliation

Tena A; Transplantation Biology Research Center, Massachusetts General Hospital, Boston, MA.

Am J Transplant ; 14(12): 2713-22, 2014 Dec.

Article in En | MEDLINE | ID: mdl-25278264

Subject(s)

Bone Marrow/immunology; CD47 Antigen/immunology; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells/immunology; Immune Tolerance/immunology; Transplantation Chimera/immunology; Animals; Animals, Genetically Modified; CD47 Antigen/metabolism; Chimerism; Galactosyltransferases/genetics; Gene Knockout Techniques; Graft Survival/immunology; Humans; Macrophages/immunology; Mice; Mice, Inbred NOD; Mice, SCID; Phagocytosis/physiology; Swine; Swine, Miniature; Transplantation Conditioning; Transplantation, Heterologous

Key words

Animal models: nonhuman primate; animal models: porcine; basic (laboratory) research/science; immunosuppression/immune modulation; tolerance: chimerism; xenotransplantation

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bone Marrow / Hematopoietic Stem Cells / Transplantation Chimera / Hematopoietic Stem Cell Transplantation / CD47 Antigen / Immune Tolerance Limits: Animals / Humans Language: En Journal: Am J Transplant Journal subject: TRANSPLANTE Year: 2014 Type: Article Affiliation country: Morocco

Fulltext

XML

PubMed Links

Search on Google