Phase II study of selumetinib (AZD6244, ARRY-142886) plus irinotecan as second-line therapy in patients with K-RAS mutated colorectal cancer.

Hochster, H S; Uboha, N; Messersmith, W; Gold, P J; ONeil, B H; Cohen, D; Denlinger, C; Cohen, S; Leichman, C G; Leichman, L; Lenz, H-J

Hochster, H S; Uboha, N; Messersmith, W; Gold, P J; ONeil, B H; Cohen, D; Denlinger, C; Cohen, S; Leichman, C G; Leichman, L; Lenz, H-J.

Affiliation

Hochster HS; Yale Cancer Center, 333 Cedar Street, New Haven, CT, 06520, USA, howard.hochster@yale.edu.

Cancer Chemother Pharmacol ; 75(1): 17-23, 2015 Jan.

Article in En | MEDLINE | ID: mdl-25322874

Subject(s)

Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Benzimidazoles/therapeutic use; Camptothecin/analogs & derivatives; Colorectal Neoplasms/drug therapy; MAP Kinase Kinase Kinases/antagonists & inhibitors; Protein Kinase Inhibitors/therapeutic use; Topoisomerase I Inhibitors/therapeutic use; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols/administration & dosage; Antineoplastic Combined Chemotherapy Protocols/adverse effects; Benzimidazoles/administration & dosage; Benzimidazoles/adverse effects; Camptothecin/administration & dosage; Camptothecin/adverse effects; Camptothecin/therapeutic use; Cohort Studies; Colorectal Neoplasms/genetics; Colorectal Neoplasms/metabolism; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Early Termination of Clinical Trials; Female; Humans; Irinotecan; MAP Kinase Kinase Kinases/metabolism; Male; Middle Aged; Mutation; Neoplasm Proteins/antagonists & inhibitors; Neoplasm Proteins/metabolism; Pilot Projects; Protein Kinase Inhibitors/administration & dosage; Protein Kinase Inhibitors/adverse effects; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins p21(ras); Survival Analysis; Topoisomerase I Inhibitors/administration & dosage; Topoisomerase I Inhibitors/adverse effects; ras Proteins/genetics; ras Proteins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzimidazoles / Camptothecin / Colorectal Neoplasms / Antineoplastic Combined Chemotherapy Protocols / MAP Kinase Kinase Kinases / Protein Kinase Inhibitors / Topoisomerase I Inhibitors Type of study: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies Language: En Journal: Cancer Chemother Pharmacol Year: 2015 Type: Article

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