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Is there any impact of HLA-DPB1 disparity in 10/10 HLA-matched unrelated hematopoietic SCT? Results of a French multicentric retrospective study.
Gagne, K; Loiseau, P; Dubois, V; Dufossé, F; Perrier, P; Dormoy, A; Jollet, I; Renac, V; Masson, D; Picard, C; Lafarge, X; Hanau, D; Quainon, F; Delbos, F; Coeffic, B; Absi, Léna; Eliaou, J-F; Moalic, V; Fort, M; de Matteis, M; Theodorou, I; Hau, F; Batho, A; Pedron, B; Caillat-Zucman, S; Marry, E; Raus, N; Yakoub-Agha, I; Cesbron, A.
Affiliation
  • Gagne K; 1] HLA Laboratory, EFS Nantes, Nantes, France [2] EA4271 EFS Nantes, Nantes, France [3] Labex Transplantex, Université Strasbourg, Strasbourg, France.
  • Loiseau P; 1] Labex Transplantex, Université Strasbourg, Strasbourg, France [2] HLA Laboratory, Inserm UMR940, AP-HP Paris Saint Louis.
  • Dubois V; HLA Laboratory, EFS Lyon, Lyon, France.
  • Dufossé F; HLA Laboratory, CHU Lille, Lille, France.
  • Perrier P; HLA Laboratory, CHU Nancy, Nancy, France.
  • Dormoy A; HLA Laboratory, EFS Besançon, Besancon, France.
  • Jollet I; HLA Laboratory, EFS Poitiers, Poitiers, France.
  • Renac V; HLA Laboratory, EFS Rennes, Rennes, France.
  • Masson D; HLA Laboratory, EFS Grenoble, Grenoble, France.
  • Picard C; HLA Laboratory, UMR 7268 Université Aix-Marseille, EFS Marseille, Marseille, France.
  • Lafarge X; HLA Laboratory, EFS Bordeaux, Bordeaux, France.
  • Hanau D; HLA Laboratory, EFS Strasbourg, Strasbourg, France.
  • Quainon F; HLA Laboratory, EFS Clermont-Ferrand, Clermont-Ferrand, France.
  • Delbos F; HLA Laboratory, AP-HP Paris Créteil, Paris, France.
  • Coeffic B; HLA Laboratory, EFS Angers, Angers, France.
  • Absi L; HLA Laboratory, EFS Saint-Etienne, Saint-Etienne, France.
  • Eliaou JF; 1] HLA Laboratory, CHU Montpellier, Montpellier, France [2] Société Francophone d'Histocompatibilité et d'Immunogénétique (SFHI), Paris, France.
  • Moalic V; HLA Laboratory, CHU Brest, Brest, France.
  • Fort M; HLA Laboratory, CHU Toulouse, Toulouse, France.
  • de Matteis M; HLA Laboratory, CHU Nice, Nice, France.
  • Theodorou I; HLA Laboratory, AP-HP Paris Pitié Salpetrière, Paris, France.
  • Hau F; HLA Laboratory, EFS Rouen, Rouen, France.
  • Batho A; HLA Laboratory, EFS Caen, Caen, France.
  • Pedron B; HLA Laboratory, AP-HP Paris Robert Debré, Paris, France.
  • Caillat-Zucman S; HLA Laboratory, AP-HP Paris Necker, Paris, France.
  • Marry E; Registre France Greffe de Moelle (RFGM), Saint Denis La Plaine, France.
  • Raus N; Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC), Hematology Department, University Hospital, Lille, France.
  • Yakoub-Agha I; Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC), Hematology Department, University Hospital, Lille, France.
  • Cesbron A; 1] HLA Laboratory, EFS Nantes, Nantes, France [2] Labex Transplantex, Université Strasbourg, Strasbourg, France.
Bone Marrow Transplant ; 50(2): 232-6, 2015 Feb.
Article in En | MEDLINE | ID: mdl-25365066
ABSTRACT
We retrospectively analyzed the impact of HLA-DPB1 mismatches in a large cohort of 1342 French patients who underwent 10/10 HLA-matched unrelated HSCT. A significant impact of HLA-DPB1 allelic mismatches (2 vs 0) was observed in severe acute GVHD (aGVHDIII-IV) (risk ratio (RR)=1.73, confidence interval (CI) 95% 1.09-2.73, P=0.019) without impact on OS, TRM, relapse and chronic GVHD (cGVHD). According to the T-cell epitope 3 (TCE3)/TCE4 HLA-DPB1 disparity algorithm, 37.6% and 58.4% pairs had nonpermissive HLA-DPB1, respectively. TCE3 and TCE4 disparities had no statistical impact on OS, TRM, relapse, aGVHD and cGVHD. When TCE3/TCE4 disparities were analyzed in the graft-vs-host or host-vs-graft (HVG) direction, only a significant impact of TCE4 nonpermissive disparities in the HVG direction was observed on relapse (RR=1.34, CI 95% 1.00-1.80, P=0.048). In conclusion, this French retrospective study shows an adverse prognosis of HLA-DPB1 mismatches (2 vs 0) on severe aGVHD and of nonpermissive TCE4 HVG disparities on relapse after HLA-matched 10/10 unrelated HSCT.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Algorithms / Hematopoietic Stem Cell Transplantation / Hematologic Neoplasms / HLA-DP beta-Chains / Unrelated Donors Type of study: Clinical_trials / Observational_studies / Risk_factors_studies Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: Bone Marrow Transplant Journal subject: TRANSPLANTE Year: 2015 Type: Article Affiliation country: France
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Algorithms / Hematopoietic Stem Cell Transplantation / Hematologic Neoplasms / HLA-DP beta-Chains / Unrelated Donors Type of study: Clinical_trials / Observational_studies / Risk_factors_studies Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: Bone Marrow Transplant Journal subject: TRANSPLANTE Year: 2015 Type: Article Affiliation country: France