Your browser doesn't support javascript.
loading
Dynamics of oligodendrocyte generation and myelination in the human brain.
Yeung, Maggie S Y; Zdunek, Sofia; Bergmann, Olaf; Bernard, Samuel; Salehpour, Mehran; Alkass, Kanar; Perl, Shira; Tisdale, John; Possnert, Göran; Brundin, Lou; Druid, Henrik; Frisén, Jonas.
Affiliation
  • Yeung MS; Department of Cell and Molecular Biology, Karolinska Institutet, 171 77 Stockholm, Sweden.
  • Zdunek S; Department of Cell and Molecular Biology, Karolinska Institutet, 171 77 Stockholm, Sweden.
  • Bergmann O; Department of Cell and Molecular Biology, Karolinska Institutet, 171 77 Stockholm, Sweden.
  • Bernard S; Institut Camille Jordan, CNRS UMR 5208, University of Lyon, 69622 Villeurbanne, France.
  • Salehpour M; Department of Physics and Astronomy, Ion Physics, Uppsala University, 751 20 Uppsala, Sweden.
  • Alkass K; Department of Cell and Molecular Biology, Karolinska Institutet, 171 77 Stockholm, Sweden; Department of Forensic Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden.
  • Perl S; NHLBI, NIH, Bethesda, MD 20892, USA.
  • Tisdale J; NHLBI, NIH, Bethesda, MD 20892, USA.
  • Possnert G; Department of Physics and Astronomy, Ion Physics, Uppsala University, 751 20 Uppsala, Sweden.
  • Brundin L; Department of Clinical Neuroscience, Department of Neurosurgery and Neurology, Karolinska University Hospital, Karolinska Institutet, 171 77 Stockholm, Sweden.
  • Druid H; Department of Forensic Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden.
  • Frisén J; Department of Cell and Molecular Biology, Karolinska Institutet, 171 77 Stockholm, Sweden. Electronic address: jonas.frisen@ki.se.
Cell ; 159(4): 766-74, 2014 Nov 06.
Article in En | MEDLINE | ID: mdl-25417154
ABSTRACT
The myelination of axons by oligodendrocytes has been suggested to be modulated by experience, which could mediate neural plasticity by optimizing the performance of the circuitry. We have assessed the dynamics of oligodendrocyte generation and myelination in the human brain. The number of oligodendrocytes in the corpus callosum is established in childhood and remains stable after that. Analysis of the integration of nuclear bomb test-derived (14)C revealed that myelin is exchanged at a high rate, whereas the oligodendrocyte population in white matter is remarkably stable in humans, with an annual exchange of 1/300 oligodendrocytes. We conclude that oligodendrocyte turnover contributes minimally to myelin modulation in human white matter and that this instead may be carried out by mature oligodendrocytes, which may facilitate rapid neural plasticity.
Subject(s)
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Aging / Oligodendroglia / Myelin Sheath Limits: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Humans / Infant / Middle aged Language: En Journal: Cell Year: 2014 Type: Article Affiliation country: Sweden
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Aging / Oligodendroglia / Myelin Sheath Limits: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Humans / Infant / Middle aged Language: En Journal: Cell Year: 2014 Type: Article Affiliation country: Sweden