Mesenchymal progenitors aging highlights a miR-196 switch targeting HOXB7 as master regulator of proliferation and osteogenesis.

Candini, Olivia; Spano, Carlotta; Murgia, Alba; Grisendi, Giulia; Veronesi, Elena; Piccinno, Maria Serena; Ferracin, Manuela; Negrini, Massimo; Giacobbi, Francesca; Bambi, Franco; Horwitz, Edwin Mark; Conte, Pierfranco; Paolucci, Paolo; Dominici, Massimo

Candini, Olivia; Spano, Carlotta; Murgia, Alba; Grisendi, Giulia; Veronesi, Elena; Piccinno, Maria Serena; Ferracin, Manuela; Negrini, Massimo; Giacobbi, Francesca; Bambi, Franco; Horwitz, Edwin Mark; Conte, Pierfranco; Paolucci, Paolo; Dominici, Massimo.

Affiliation

Candini O; Department of Medical and Surgical Sciences for Children & Adults, University-Hospital of Modena and Reggio Emilia, Modena, Italy.

Stem Cells ; 33(3): 939-50, 2015 Mar.

Article in En | MEDLINE | ID: mdl-25428821

Subject(s)

Homeodomain Proteins/metabolism; Mesenchymal Stem Cells/cytology; MicroRNAs/metabolism; Adult; Aged; Animals; Cell Differentiation/physiology; Cell Proliferation/physiology; Female; Homeodomain Proteins/genetics; Humans; Male; Mesenchymal Stem Cells/metabolism; Mice; MicroRNAs/genetics; Middle Aged; Osteogenesis

Key words

Aging; Bone; Bone marrow stromal cells; Homeobox genes

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Homeodomain Proteins / MicroRNAs / Mesenchymal Stem Cells Type of study: Prognostic_studies Limits: Adult / Aged / Animals / Female / Humans / Male / Middle aged Language: En Journal: Stem Cells Year: 2015 Type: Article Affiliation country: Italy

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