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Mechanism of cisplatin proximal tubule toxicity revealed by integrating transcriptomics, proteomics, metabolomics and biokinetics.
Wilmes, Anja; Bielow, Chris; Ranninger, Christina; Bellwon, Patricia; Aschauer, Lydia; Limonciel, Alice; Chassaigne, Hubert; Kristl, Theresa; Aiche, Stephan; Huber, Christian G; Guillou, Claude; Hewitt, Philipp; Leonard, Martin O; Dekant, Wolfgang; Bois, Frederic; Jennings, Paul.
Affiliation
  • Wilmes A; Division of Physiology, Department of Physiology and Medical Physics, Medical University of Innsbruck, Innsbruck 6020, Austria. Electronic address: Anja.Wilmes@i-med.ac.at.
  • Bielow C; Institute of Computer Science, Department of Mathematics and Computer Science, Freie Universität Berlin, Berlin 14195, Germany.
  • Ranninger C; Department of Molecular Biology, Division of Chemistry and Bioanalytics, University of Salzburg, Salzburg 5020, Austria.
  • Bellwon P; Department of Toxicology, University of Würzburg, Würzburg 97078, Germany.
  • Aschauer L; Division of Physiology, Department of Physiology and Medical Physics, Medical University of Innsbruck, Innsbruck 6020, Austria.
  • Limonciel A; Division of Physiology, Department of Physiology and Medical Physics, Medical University of Innsbruck, Innsbruck 6020, Austria.
  • Chassaigne H; European Commission, Joint Research Centre (JRC), Institute for Health and Consumer Protection, Chemical Assessment and Testing Unit, Via Enrico Fermi 2749, I-21027 Ispra, Italy.
  • Kristl T; Department of Molecular Biology, Division of Chemistry and Bioanalytics, University of Salzburg, Salzburg 5020, Austria.
  • Aiche S; Institute of Computer Science, Department of Mathematics and Computer Science, Freie Universität Berlin, Berlin 14195, Germany.
  • Huber CG; Department of Toxicology, University of Würzburg, Würzburg 97078, Germany.
  • Guillou C; European Commission, Joint Research Centre (JRC), Institute for Health and Consumer Protection, Chemical Assessment and Testing Unit, Via Enrico Fermi 2749, I-21027 Ispra, Italy.
  • Hewitt P; Merck KGaA, Merck Serono, Nonclinical Safety, Darmstadt 64293, Germany.
  • Leonard MO; Centre for Radiation, Chemical and Environmental Hazard, Public Health England, Chilton, Didcot OX11 0RQ, UK.
  • Dekant W; Department of Toxicology, University of Würzburg, Würzburg 97078, Germany.
  • Bois F; Université de Technologie de Compiègne, Compiègne Cedex 60205, France.
  • Jennings P; Division of Physiology, Department of Physiology and Medical Physics, Medical University of Innsbruck, Innsbruck 6020, Austria.
Toxicol In Vitro ; 30(1 Pt A): 117-27, 2015 Dec 25.
Article in En | MEDLINE | ID: mdl-25450742
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cisplatin / Proteomics / Metabolomics / Transcriptome / Kidney Tubules, Proximal Type of study: Prognostic_studies Limits: Humans Language: En Journal: Toxicol In Vitro Journal subject: TOXICOLOGIA Year: 2015 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cisplatin / Proteomics / Metabolomics / Transcriptome / Kidney Tubules, Proximal Type of study: Prognostic_studies Limits: Humans Language: En Journal: Toxicol In Vitro Journal subject: TOXICOLOGIA Year: 2015 Type: Article