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Access to large cyclic peptides by a one-pot two-peptide segment ligation/cyclization process.
Boll, Emmanuelle; Ebran, Jean-Philippe; Drobecq, Hervé; El-Mahdi, Ouafâa; Raibaut, Laurent; Ollivier, Nathalie; Melnyk, Oleg.
Affiliation
  • Boll E; UMR CNRS 8161, Université de Lille, Pasteur Institute of Lille 59021 Lille, France.
Org Lett ; 17(1): 130-3, 2015 Jan 02.
Article in En | MEDLINE | ID: mdl-25506740
ABSTRACT
The use of the N-acetoacetyl protecting group for N-terminal cysteine residue enabled creation of an efficient and mild one-pot native chemical ligation/SEA ligation sequence giving access to large cyclic peptides.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides, Cyclic Language: En Journal: Org Lett Journal subject: BIOQUIMICA Year: 2015 Type: Article Affiliation country: France
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides, Cyclic Language: En Journal: Org Lett Journal subject: BIOQUIMICA Year: 2015 Type: Article Affiliation country: France