Inhibition of placental growth factor in renal cell carcinoma.

Bessho, Hideharu; Wong, Bernice; Huang, Dan; Siew, Ee Yan; Huang, Dachuan; Tan, Jing; Ong, Choon Kiat; Tan, Soo Yong; Matsumoto, Kazumasa; Iwamura, Masatsugu; Teh, Bin Tean

Bessho, Hideharu; Wong, Bernice; Huang, Dan; Siew, Ee Yan; Huang, Dachuan; Tan, Jing; Ong, Choon Kiat; Tan, Soo Yong; Matsumoto, Kazumasa; Iwamura, Masatsugu; Teh, Bin Tean.

Affiliation

Bessho H; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore, Singapore Program in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore, Singapore Department of Urology, Kitasato University School of Medicine, Kanagawa, Japan hideji56@gmail.com.
Wong B; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore, Singapore Program in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore, Singapore.
Huang D; Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, MI, U.S.A.
Siew EY; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore, Singapore Program in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore, Singapore.
Huang D; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore, Singapore Program in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore, Singapore.
Tan J; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore, Singapore Program in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore, Singapore.
Ong CK; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore, Singapore Program in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore, Singapore.
Tan SY; Department of Pathology, Singapore General Hospital, Singapore, Singapore.
Matsumoto K; Department of Urology, Kitasato University School of Medicine, Kanagawa, Japan.
Iwamura M; Department of Urology, Kitasato University School of Medicine, Kanagawa, Japan.
Teh BT; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore, Singapore Program in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore, Singapore Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.

Anticancer Res ; 35(1): 531-41, 2015 Jan.

Article in En | MEDLINE | ID: mdl-25550599

Subject(s)

Antibodies, Monoclonal/therapeutic use; Antineoplastic Agents/therapeutic use; Carcinoma, Renal Cell/drug therapy; Kidney Neoplasms/drug therapy; Pregnancy Proteins/antagonists & inhibitors; Animals; Antibodies, Monoclonal/pharmacology; Antibodies, Monoclonal, Humanized; Antineoplastic Agents/pharmacology; Carcinoma, Renal Cell/blood supply; Carcinoma, Renal Cell/metabolism; Carcinoma, Renal Cell/pathology; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Humans; Indoles/pharmacology; Kidney Neoplasms/blood supply; Kidney Neoplasms/metabolism; Kidney Neoplasms/pathology; Mice, Nude; Neovascularization, Pathologic/drug therapy; Placenta Growth Factor; Pregnancy Proteins/blood; Pyrroles/pharmacology; Sunitinib; Transcriptome/drug effects; Tumor Burden/drug effects; Xenograft Model Antitumor Assays

Key words

Placental growth factor (PlGF); antiangiogenic therapy; renal cell carcinoma; sunitinib resistance

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Collection: 01-internacional Database: MEDLINE Main subject: Pregnancy Proteins / Carcinoma, Renal Cell / Kidney Neoplasms / Antibodies, Monoclonal / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Anticancer Res Year: 2015 Type: Article Affiliation country: Japan

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