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A long-standing mystery solved: the formation of 3-hydroxydesloratadine is catalyzed by CYP2C8 but prior glucuronidation of desloratadine by UDP-glucuronosyltransferase 2B10 is an obligatory requirement.
Kazmi, Faraz; Barbara, Joanna E; Yerino, Phyllis; Parkinson, Andrew.
Affiliation
  • Kazmi F; XenoTech, LLC, Lenexa, Kansas (F.K., J.E.B., P.Y.); and XPD Consulting, Shawnee, Kansas (A.P.) fkazmi@xenotechllc.com.
  • Barbara JE; XenoTech, LLC, Lenexa, Kansas (F.K., J.E.B., P.Y.); and XPD Consulting, Shawnee, Kansas (A.P.).
  • Yerino P; XenoTech, LLC, Lenexa, Kansas (F.K., J.E.B., P.Y.); and XPD Consulting, Shawnee, Kansas (A.P.).
  • Parkinson A; XenoTech, LLC, Lenexa, Kansas (F.K., J.E.B., P.Y.); and XPD Consulting, Shawnee, Kansas (A.P.).
Drug Metab Dispos ; 43(4): 523-33, 2015 Apr.
Article in En | MEDLINE | ID: mdl-25595597
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aryl Hydrocarbon Hydroxylases / Glucuronosyltransferase / Loratadine / Glucuronides / Cytochrome P-450 CYP2C8 Limits: Animals / Humans Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2015 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aryl Hydrocarbon Hydroxylases / Glucuronosyltransferase / Loratadine / Glucuronides / Cytochrome P-450 CYP2C8 Limits: Animals / Humans Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2015 Type: Article