Human papillomavirus and breast cancer: no evidence of association in a Spanish set of cases.
Anticancer Res
; 35(2): 851-6, 2015 Feb.
Article
in En
| MEDLINE
| ID: mdl-25667466
ABSTRACT
BACKGROUND/AIM:
Great controversy exists about the association between Human Papillomavirus (HPV) and breast tumors. The aim of this study was to explore the presence of HPV DNA in a large set of breast cancer cases. MATERIALS ANDMETHODS:
Techniques used followed the standards for an international retrospective survey of HPV-DNA genotyping, coordinated by our own group and the DDL Laboratories in Rijswijk, the Netherlands. Paraffin-embedded samples were used. SPF-10 broad-spectrum primers were applied, followed by deoxyribonucleic acid enzyme immunoassay and genotyping by reverse-line probe assay.RESULTS:
A total of 78 samples were included in the study, 2 of benign conditions and 76 carcinomas, including different histological subtypes. HPV was not present in any of the specimens studied irrespective of histology, hormonal status and stage of disease.CONCLUSION:
Our data do not support the involvement of HPV in breast carcinogenesis as no evidence of its presence was found.Key words
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Papillomaviridae
/
Breast Neoplasms
Type of study:
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Middle aged
Country/Region as subject:
Europa
Language:
En
Journal:
Anticancer Res
Year:
2015
Type:
Article
Affiliation country:
Spain