Somatostatin effect in postprandial hypoglycemia.
Metabolism
; 38(6): 568-71, 1989 Jun.
Article
in En
| MEDLINE
| ID: mdl-2566889
ABSTRACT
The effect of the administration of oral glucose with or without a simultaneous intravenous somatostatin infusion on blood glucose, immunoreactive insulin, C-peptide, and glucagon levels in seven patients with idiopathic postprandial hypoglycemia was studied. Oral glucose alone induced an excessive insulin response and hypoglycemia, whereas a slight suppression in glucagon levels without any increase at the hypoglycemic nadir was observed. The simultaneous administration of somatostatin significantly reduced the insulin response and induced a slower rise of blood glucose; no hypoglycemia developed. Only minor variations in glucagon were observed with respect to the basal test. A rebound in insulin, C-peptide, and glucagon levels was observed at the end of the somatostatin infusion. These data show that somatostatin can suppress glucose-induced hypoglycemia in these subjects, thus suggesting that its long-acting analogues might be worth a therapeutic trial in severe idiopathic postprandial hypoglycemia.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Somatostatin
/
Food
/
Hypoglycemia
Type of study:
Etiology_studies
Limits:
Adult
/
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Metabolism
Year:
1989
Type:
Article
Affiliation country:
Italy