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Transforming growth factor ß2 promotes transcription of COX2 and EP4, leading to a prostaglandin E2-driven autostimulatory loop that enhances virulence of Theileria annulata-transformed macrophages.
Haidar, Malak; Echebli, Nadia; Ding, Ying; Kamau, Everlyn; Langsley, Gordon.
Affiliation
  • Haidar M; Laboratoire de Biologie Cellulaire Comparative des Apicomplexes, Faculté de Médicine, Université Paris Descartes-Sorbonne Paris Cité, Paris, France, and Inserm U1016, Cnrs UMR8104, Cochin Institute, Paris, France.
  • Echebli N; Laboratoire de Biologie Cellulaire Comparative des Apicomplexes, Faculté de Médicine, Université Paris Descartes-Sorbonne Paris Cité, Paris, France, and Inserm U1016, Cnrs UMR8104, Cochin Institute, Paris, France.
  • Ding Y; Laboratoire de Biologie Cellulaire Comparative des Apicomplexes, Faculté de Médicine, Université Paris Descartes-Sorbonne Paris Cité, Paris, France, and Inserm U1016, Cnrs UMR8104, Cochin Institute, Paris, France.
  • Kamau E; Laboratoire de Biologie Cellulaire Comparative des Apicomplexes, Faculté de Médicine, Université Paris Descartes-Sorbonne Paris Cité, Paris, France, and Inserm U1016, Cnrs UMR8104, Cochin Institute, Paris, France.
  • Langsley G; Laboratoire de Biologie Cellulaire Comparative des Apicomplexes, Faculté de Médicine, Université Paris Descartes-Sorbonne Paris Cité, Paris, France, and Inserm U1016, Cnrs UMR8104, Cochin Institute, Paris, France gordon.langsley@inserm.fr.
Infect Immun ; 83(5): 1869-80, 2015 May.
Article in En | MEDLINE | ID: mdl-25690101
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription, Genetic / Dinoprostone / Theileria annulata / Cyclooxygenase 2 / Transforming Growth Factor beta2 / Receptors, Prostaglandin E, EP4 Subtype / Macrophages Limits: Animals Language: En Journal: Infect Immun Year: 2015 Type: Article Affiliation country: France
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription, Genetic / Dinoprostone / Theileria annulata / Cyclooxygenase 2 / Transforming Growth Factor beta2 / Receptors, Prostaglandin E, EP4 Subtype / Macrophages Limits: Animals Language: En Journal: Infect Immun Year: 2015 Type: Article Affiliation country: France