Eight-membered ring-containing jadomycins: implications for non-enzymatic natural products biosynthesis.

Robertson, Andrew W; Martinez-Farina, Camilo F; Smithen, Deborah A; Yin, Huimin; Monro, Susan; Thompson, Alison; McFarland, Sherri A; Syvitski, Raymond T; Jakeman, David L

Robertson, Andrew W; Martinez-Farina, Camilo F; Smithen, Deborah A; Yin, Huimin; Monro, Susan; Thompson, Alison; McFarland, Sherri A; Syvitski, Raymond T; Jakeman, David L.

Affiliation

Robertson AW; Department of Chemistry and â¥College of Pharmacy, Dalhousie University , Halifax, Nova Scotia B3H 4R2, Canada.

J Am Chem Soc ; 137(9): 3271-5, 2015 Mar 11.

Article in En | MEDLINE | ID: mdl-25692677

Subject(s)

Antineoplastic Agents/pharmacology; Biological Products/chemistry; Heterocyclic Compounds, 4 or More Rings/chemistry; Streptomyces/metabolism; Acylation; Amino Acids, Neutral/chemistry; Antineoplastic Agents/chemistry; Biological Products/chemical synthesis; Cell Line, Tumor/drug effects; Drug Screening Assays, Antitumor; Fermentation; Heterocyclic Compounds, 4 or More Rings/isolation & purification; Heterocyclic Compounds, 4 or More Rings/metabolism; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Ornithine/chemistry; Streptomyces/growth & development; Structure-Activity Relationship; Tandem Mass Spectrometry

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Streptomyces / Biological Products / Heterocyclic Compounds, 4 or More Rings / Antineoplastic Agents Limits: Humans Language: En Journal: J Am Chem Soc Year: 2015 Type: Article Affiliation country: Canada

Fulltext

XML

PubMed Links

Search on Google