Spontaneous calcification process in primary renal cells from a medullary sponge kidney patient harbouring a GDNF mutation.

Mezzabotta, Federica; Cristofaro, Rosalba; Ceol, Monica; Del Prete, Dorella; Priante, Giovanna; Familiari, Alessandra; Fabris, Antonia; D'Angelo, Angela; Gambaro, Giovanni; Anglani, Franca

Mezzabotta, Federica; Cristofaro, Rosalba; Ceol, Monica; Del Prete, Dorella; Priante, Giovanna; Familiari, Alessandra; Fabris, Antonia; D'Angelo, Angela; Gambaro, Giovanni; Anglani, Franca.

Affiliation

Mezzabotta F; Laboratory of Histomorphology and Molecular Biology of the Kidney, Nephrology Division, Department of Medicine DIMED, University of Padua, Padua, Italy.

J Cell Mol Med ; 19(4): 889-902, 2015 Apr.

Article in En | MEDLINE | ID: mdl-25692823

Subject(s)

Calcinosis; Glial Cell Line-Derived Neurotrophic Factor/genetics; Medullary Sponge Kidney/genetics; Mutation; Actins/metabolism; Aged; CD146 Antigen/metabolism; Calcification, Physiologic; Cell Line; Cells, Cultured; Female; Humans; Immunohistochemistry; Kidney/metabolism; Kidney/pathology; Kidney/ultrastructure; Medullary Sponge Kidney/metabolism; Medullary Sponge Kidney/pathology; Microscopy, Electron, Scanning; Middle Aged; Muscle, Smooth/chemistry; Osteonectin/genetics; Osteonectin/metabolism; Osteopontin/genetics; Osteopontin/metabolism; Primary Cell Culture; RNA Interference; Reverse Transcriptase Polymerase Chain Reaction; Vimentin/metabolism; Zonula Occludens-1 Protein

Key words

GDNF; medullary sponge kidney; mesenchymal stromal stem cells; nephrocalcinosis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Calcinosis / Glial Cell Line-Derived Neurotrophic Factor / Medullary Sponge Kidney / Mutation Limits: Aged / Female / Humans / Middle aged Language: En Journal: J Cell Mol Med Journal subject: BIOLOGIA MOLECULAR Year: 2015 Type: Article Affiliation country: Italy

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