Preclinical pharmacokinetics, pharmacodynamics, and efficacy of RG7116: a novel humanized, glycoengineered anti-HER3 antibody.

Meneses-Lorente, Georgina; Friess, Thomas; Kolm, Irene; Hölzlwimmer, Gabriele; Bader, Sabine; Meille, Christophe; Thomas, Marlene; Bossenmaier, Birgit

Meneses-Lorente, Georgina; Friess, Thomas; Kolm, Irene; Hölzlwimmer, Gabriele; Bader, Sabine; Meille, Christophe; Thomas, Marlene; Bossenmaier, Birgit.

Affiliation

Meneses-Lorente G; Pharma Research and Early Development, Clinical Pharmacology, Roche Innovation Center Welwyn, Welwyn Garden City, UK.

Cancer Chemother Pharmacol ; 75(4): 837-50, 2015 Apr.

Article in En | MEDLINE | ID: mdl-25702049

Subject(s)

Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Glycoproteins; Hypopharyngeal Neoplasms/drug therapy; Receptor, ErbB-3/antagonists & inhibitors; Animals; Antibodies, Monoclonal, Humanized/pharmacokinetics; Antibodies, Monoclonal, Humanized/pharmacology; Antibodies, Monoclonal, Humanized/therapeutic use; Antineoplastic Agents/pharmacokinetics; Antineoplastic Agents/pharmacology; Antineoplastic Agents/therapeutic use; Cell Line, Tumor; Dose-Response Relationship, Drug; Glycoproteins/pharmacokinetics; Glycoproteins/pharmacology; Glycoproteins/therapeutic use; Humans; Hypopharyngeal Neoplasms/metabolism; Hypopharyngeal Neoplasms/pathology; Macaca fascicularis; Mice, SCID; Mouth Mucosa/drug effects; Mouth Mucosa/metabolism; Skin/drug effects; Skin/metabolism; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Glycoproteins / Hypopharyngeal Neoplasms / Receptor, ErbB-3 / Antibodies, Monoclonal, Humanized / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: Cancer Chemother Pharmacol Year: 2015 Type: Article Affiliation country: United kingdom

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