Exome sequencing and array-based comparative genomic hybridisation analysis of preferential 6-methylmercaptopurine producers.

Chua, E W; Cree, S; Barclay, M L; Doudney, K; Lehnert, K; Aitchison, A; Kennedy, M A

Chua, E W; Cree, S; Barclay, M L; Doudney, K; Lehnert, K; Aitchison, A; Kennedy, M A.

Affiliation

Chua EW; Carney Centre for Pharmacogenomics and Department of Pathology, University of Otago Christchurch, Christchurch, New Zealand.
Cree S; Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Barclay ML; Carney Centre for Pharmacogenomics and Department of Pathology, University of Otago Christchurch, Christchurch, New Zealand.
Doudney K; Department of Clinical Pharmacology, Christchurch Hospital, Canterbury District Health Board, Christchurch, New Zealand.
Lehnert K; Department of Medicine, University of Otago Christchurch, Christchurch, New Zealand.
Aitchison A; Molecular Pathology, Canterbury Health Laboratories, Christchurch, New Zealand.
Kennedy MA; School of Biological Sciences, University of Auckland, Auckland, New Zealand.

Pharmacogenomics J ; 15(5): 414-21, 2015 Oct.

Article in En | MEDLINE | ID: mdl-25752523

Subject(s)

Colitis, Ulcerative/genetics; Crohn Disease/genetics; Drug Resistance/genetics; Hepatitis, Autoimmune/genetics; Adult; Azathioprine/administration & dosage; Colitis, Ulcerative/drug therapy; Colitis, Ulcerative/pathology; Comparative Genomic Hybridization; Crohn Disease/drug therapy; Crohn Disease/pathology; DNA Copy Number Variations/genetics; Exome/genetics; Female; Genome-Wide Association Study; Hepatitis, Autoimmune/drug therapy; Hepatitis, Autoimmune/pathology; High-Throughput Nucleotide Sequencing; Humans; Male; Mercaptopurine/administration & dosage; Mercaptopurine/analogs & derivatives; Metabolic Networks and Pathways/genetics; Methyltransferases/genetics; Methyltransferases/metabolism; Middle Aged; Mutation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Resistance / Colitis, Ulcerative / Crohn Disease / Hepatitis, Autoimmune Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Pharmacogenomics J Journal subject: BIOLOGIA MOLECULAR / FARMACOLOGIA Year: 2015 Type: Article Affiliation country: New Zealand

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