Adaptive mutations alter antibody structure and dynamics during affinity maturation.

Adhikary, Ramkrishna; Yu, Wayne; Oda, Masayuki; Walker, Ross C; Chen, Tingjian; Stanfield, Robyn L; Wilson, Ian A; Zimmermann, Jörg; Romesberg, Floyd E

Adhikary, Ramkrishna; Yu, Wayne; Oda, Masayuki; Walker, Ross C; Chen, Tingjian; Stanfield, Robyn L; Wilson, Ian A; Zimmermann, Jörg; Romesberg, Floyd E.

Affiliation

Oda M; §Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, 1-5, Hangi-cho, Shimogamo, Sakyo-ku, Kyoto 606-8522, Japan.
Walker RC; â¥Department of Chemistry and Biochemistry and San Diego Supercomputer Center, University of California, San Diego, La Jolla, California 92093, United States.

Biochemistry ; 54(11): 2085-93, 2015 Mar 24.

Article in En | MEDLINE | ID: mdl-25756188

Subject(s)

Antibodies, Monoclonal/chemistry; Antibody Specificity; Evolution, Molecular; Immunoglobulin G/chemistry; Models, Immunological; Models, Molecular; Mutation; Amino Acid Substitution; Animals; Antibodies, Monoclonal/genetics; Antibodies, Monoclonal/metabolism; Antibody Affinity; Binding Sites, Antibody; Fluorescent Dyes/chemistry; Fluorescent Dyes/metabolism; Hybridomas; Hydrogen Bonding; Immunoglobulin G/genetics; Immunoglobulin G/metabolism; Kinetics; Mice; Protein Conformation; Protein Folding; Protein Stability; Pyrenes/antagonists & inhibitors; Pyrenes/chemistry; Pyrenes/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin G / Models, Molecular / Models, Immunological / Evolution, Molecular / Antibodies, Monoclonal / Antibody Specificity / Mutation Limits: Animals Language: En Journal: Biochemistry Year: 2015 Type: Article

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