A novel cysteine cathepsin inhibitor yields macrophage cell death and mammary tumor regression.

Salpeter, S J; Pozniak, Y; Merquiol, E; Ben-Nun, Y; Geiger, T; Blum, G

Salpeter, S J; Pozniak, Y; Merquiol, E; Ben-Nun, Y; Geiger, T; Blum, G.

Affiliation

Salpeter SJ; Institute for Drug Research, The School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Pozniak Y; Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel.
Merquiol E; Institute for Drug Research, The School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Ben-Nun Y; Institute for Drug Research, The School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Geiger T; Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel.
Blum G; Institute for Drug Research, The School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.

Oncogene ; 34(50): 6066-78, 2015 Dec 10.

Article in En | MEDLINE | ID: mdl-25798843

Subject(s)

Cathepsins/antagonists & inhibitors; Macrophages/physiology; Mammary Neoplasms, Experimental/drug therapy; Animals; Apoptosis; Autophagy; Cathepsins/physiology; Cell Polarity; Female; Macrophages/drug effects; Mammary Neoplasms, Experimental/metabolism; Mice; Mice, Inbred BALB C; Oxidative Stress; Reactive Oxygen Species/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cathepsins / Macrophages / Mammary Neoplasms, Experimental Limits: Animals Language: En Journal: Oncogene Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2015 Type: Article Affiliation country: Israel

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