Islet adaptation to obesity and insulin resistance in WNIN/GR-Ob rats.

Singh, Himadri; Ganneru, Sireesha; Malakapalli, Venkata; Chalasani, Maniprabha; Nappanveettil, Giridharan; Bhonde, Ramesh R; Venkatesan, Vijayalakshmi

Singh, Himadri; Ganneru, Sireesha; Malakapalli, Venkata; Chalasani, Maniprabha; Nappanveettil, Giridharan; Bhonde, Ramesh R; Venkatesan, Vijayalakshmi.

Affiliation

Singh H; a Biochemistry/Stem Cell Research; National Institute of Nutrition; Indian Council of Medical Research ; Hyderabad , India.

Islets ; 6(5-6): e998099, 2014.

Article in En | MEDLINE | ID: mdl-25833252

Subject(s)

Insulin Resistance/physiology; Islets of Langerhans/physiopathology; Obesity/physiopathology; Adaptation, Physiological/physiology; Age Factors; Animals; Body Weight; Female; Gene Expression/physiology; Glucagon/metabolism; Insulin/metabolism; Insulin-Secreting Cells/pathology; Insulin-Secreting Cells/physiology; Islets of Langerhans/cytology; Islets of Langerhans/pathology; Islets of Langerhans/ultrastructure; Microscopy, Electron, Scanning; Organ Size; Oxidative Stress/physiology; Rats; Rats, Mutant Strains/physiology; Somatostatin/metabolism

Key words

ANOVA, one-way analysis of variance; BM-MSCs, bone marrow derived mesenchymal stem cells; DAPI, 4',6-diamidino-2-phenylindol; DTZ, Dithizone; FBG, fasting blood glucose; H&E, hematoxylin and eosin stain; HI, hyperinsulinemia; HOMA-IR, homeostatic model assessment for insulin resistance; IGT, impaired glucose tolerance; IHC, immunohistochemistry; IR, insulin resistance; KRBH, krebs ringer bicarbonate; MS, metabolic syndrome; NCLAS, National Center for Laboratory Animal Sciences; NIN, National Institute of Nutrition; PBS, phosphate buffered saline; ROS, reactive oxygen species; SEM, scanning electron microscope; T2D, type 2 diabetes; TBARS, thiobarbituric acid reactive substances; TEM, transmission electron microscopy; TNFα, tumor necrosis factors; WNIN, Wistar rats raised at National Institute of Nutrition; WNIN/GR-Ob mutant rats; hyperinsulinemia; hypertrophy; insulin resistance; islets

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Insulin Resistance / Islets of Langerhans / Obesity Type of study: Prognostic_studies Limits: Animals Language: En Journal: Islets Journal subject: ENDOCRINOLOGIA / GASTROENTEROLOGIA Year: 2014 Type: Article Affiliation country: India

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