Influence of drug physicochemical characteristics on in vitro transdermal absorption of hydrophobic drug nanosuspensions.
Drug Dev Ind Pharm
; 41(12): 1997-2005, 2015.
Article
in En
| MEDLINE
| ID: mdl-25835068
ABSTRACT
The purpose of this paper was to study the influence of drug physicochemical characteristics on in vitro transdermal absorption of hydrophobic drug nanosuspensions. Four drug nanosuspensions were produced by high-pressure homogenization technique, which were the same in stabilizer and similar in particle size. Differential scanning calorimetry and powder X-ray diffraction analysis showed that the crystalline state of the nanocrystals did not change. In vitro permeation study demonstrated that the drug nanosuspensions have a higher rate of permeation that ranged from 1.69- to 3.74-fold compared to drug microsuspensions. Correlation analysis between drug physicochemical properties and Jss revealed that log P and pKa were factors that influenced the in vitro transdermal absorption of hydrophobic drug nanosuspensions, and drugs with a log P value around 3 and a higher pKa value (when pKa < pH+2) would gain higher Jss in this paper.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin Absorption
/
Nanoparticles
/
Chemical Phenomena
/
Hydrophobic and Hydrophilic Interactions
Limits:
Animals
Language:
En
Journal:
Drug Dev Ind Pharm
Year:
2015
Type:
Article