Ibrutinib in previously treated Waldenström's macroglobulinemia.

Treon, Steven P; Tripsas, Christina K; Meid, Kirsten; Warren, Diane; Varma, Gaurav; Green, Rebecca; Argyropoulos, Kimon V; Yang, Guang; Cao, Yang; Xu, Lian; Patterson, Christopher J; Rodig, Scott; Zehnder, James L; Aster, Jon C; Harris, Nancy Lee; Kanan, Sandra; Ghobrial, Irene; Castillo, Jorge J; Laubach, Jacob P; Hunter, Zachary R; Salman, Zeena; Li, Jianling; Cheng, Mei; Clow, Fong; Graef, Thorsten; Palomba, M Lia; Advani, Ranjana H

Treon, Steven P; Tripsas, Christina K; Meid, Kirsten; Warren, Diane; Varma, Gaurav; Green, Rebecca; Argyropoulos, Kimon V; Yang, Guang; Cao, Yang; Xu, Lian; Patterson, Christopher J; Rodig, Scott; Zehnder, James L; Aster, Jon C; Harris, Nancy Lee; Kanan, Sandra; Ghobrial, Irene; Castillo, Jorge J; Laubach, Jacob P; Hunter, Zachary R; Salman, Zeena; Li, Jianling; Cheng, Mei; Clow, Fong; Graef, Thorsten; Palomba, M Lia; Advani, Ranjana H.

Affiliation

Treon SP; From the Bing Center for Waldenström's Macroglobulinemia, Dana-Farber Cancer Institute (S.P.T., C.K.T., K.M., D.W., G.Y., Y.C., L.X., C.J.P., S.K., I.G., J.J.C., J.P.L., Z.R.H.), Harvard Medical School (S.P.T., G.Y., Y.C., S.R., J.C.A., N.L.H., I.G., J.J.C., J.P.L.), Department of Pathology, Brigham and Women's Hospital (S.R., J.C.A.), Department of Pathology, Massachusetts General Hospital (N.L.H.), and Department of Pathology, Boston University Medical Center (Z.R.H.) - all in Boston; Memorial

N Engl J Med ; 372(15): 1430-40, 2015 Apr 09.

Article in En | MEDLINE | ID: mdl-25853747

Subject(s)

Protein Kinase Inhibitors/therapeutic use; Protein-Tyrosine Kinases/antagonists & inhibitors; Pyrazoles/therapeutic use; Pyrimidines/therapeutic use; Waldenstrom Macroglobulinemia/drug therapy; Adenine/analogs & derivatives; Adult; Agammaglobulinaemia Tyrosine Kinase; Aged; Aged, 80 and over; Disease-Free Survival; Female; Hemoglobins/analysis; Humans; Immunoglobulin M/blood; Kaplan-Meier Estimate; Male; Middle Aged; Mutation; Myeloid Differentiation Factor 88/genetics; Piperidines; Prospective Studies; Protein Kinase Inhibitors/adverse effects; Pyrazoles/adverse effects; Pyrimidines/adverse effects; Receptors, CXCR4/genetics; Survival Rate; Waldenstrom Macroglobulinemia/blood; Waldenstrom Macroglobulinemia/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Pyrimidines / Protein-Tyrosine Kinases / Waldenstrom Macroglobulinemia / Protein Kinase Inhibitors Type of study: Clinical_trials / Observational_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: N Engl J Med Year: 2015 Type: Article

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