Development of mixed connective tissue disease and Sjögren's syndrome in a patient with trisomy X.
Lupus
; 24(11): 1217-20, 2015 Oct.
Article
in En
| MEDLINE
| ID: mdl-25854827
ABSTRACT
Increased risk of developing systemic lupus erythematosus (SLE) has been reported in patients with Klinefelter syndrome. Here, we describe a 16-year-old Japanese patient with trisomy X (47,XXX) who developed mixed connective tissue disease (MCTD) and Sjögren's syndrome. She had polyarthritis, edematous fingers with Raynaud's phenomenon, sicca syndrome, interstitial lung disease, possible myositis, and was positive for anti-nuclear antibody, anti-nRNP antibody and rheumatoid factor. This is the first report in the literature of a case of MCTD with female polysomy X, which further supports the link between the presence of extra X chromosome(s) and the development of autoimmune diseases.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sjogren's Syndrome
/
Sex Chromosome Disorders of Sex Development
/
Mixed Connective Tissue Disease
Limits:
Adolescent
/
Female
/
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
Lupus
Journal subject:
REUMATOLOGIA
Year:
2015
Type:
Article
Affiliation country:
Japan