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A Thr72Ala polymorphism in the NKG2D gene is associated with early symptomatic congenital cytomegalovirus disease.
Taniguchi, Rumi; Koyano, Shin; Suzutani, Tatsuo; Goishi, Keiji; Ito, Yushi; Morioka, Ichiro; Nakamura, Hiroyuki; Yamada, Hideto; Oka, Akira; Inoue, Naoki.
Affiliation
  • Taniguchi R; Department of Virology I, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan.
Infection ; 43(3): 353-9, 2015 Jun.
Article in En | MEDLINE | ID: mdl-25861030
ABSTRACT
The potential risk factors for congenital cytomegalovirus (cCMV) infection or development of disease remain unclear. Here, we investigated the genetic polymorphisms in natural killer (NK) group 2, member D (NKG2D), an activating receptor expressed on NK cells, and in MHC class I-related chains A, the ligand of NKG2D, in 87 cCMV cases, and found that there was a significant association between cCMV disease and a single nucleotide polymorphism, Thr72Ala, in NKG2D.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cytomegalovirus Infections / Genetic Predisposition to Disease / Mutation, Missense / NK Cell Lectin-Like Receptor Subfamily K Type of study: Diagnostic_studies / Observational_studies / Risk_factors_studies Limits: Child / Child, preschool / Female / Humans / Infant / Male / Newborn Language: En Journal: Infection Year: 2015 Type: Article Affiliation country: Japan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cytomegalovirus Infections / Genetic Predisposition to Disease / Mutation, Missense / NK Cell Lectin-Like Receptor Subfamily K Type of study: Diagnostic_studies / Observational_studies / Risk_factors_studies Limits: Child / Child, preschool / Female / Humans / Infant / Male / Newborn Language: En Journal: Infection Year: 2015 Type: Article Affiliation country: Japan