Combining BRAF(V) (600E) inhibition with modulators of the mitochondrial bioenergy metabolism to overcome drug resistance in metastatic melanoma.

Livingstone, Elisabeth; Swann, Suzanne; Lilla, Carmen; Schadendorf, Dirk; Roesch, Alexander

Livingstone, Elisabeth; Swann, Suzanne; Lilla, Carmen; Schadendorf, Dirk; Roesch, Alexander.

Affiliation

Livingstone E; Department of Dermatology, University Hospital Essen, Essen, Germany.
Swann S; GlaxoSmithKline, Collegeville, PA, USA.
Lilla C; GlaxoSmithKline GmbH & Co. KG, Munich, Germany.
Schadendorf D; Department of Dermatology, University Hospital Essen, Essen, Germany.
Roesch A; Department of Dermatology, University Hospital Essen, Essen, Germany.

Exp Dermatol ; 24(9): 709-10, 2015 Sep.

Article in En | MEDLINE | ID: mdl-25865258

Subject(s)

Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Drug Resistance, Neoplasm; Melanoma/drug therapy; Skin Neoplasms/drug therapy; Benzodiazepines/administration & dosage; Drug Resistance, Multiple; Drug Synergism; Humans; Hydrazines/administration & dosage; Imidazoles/administration & dosage; Indoles/administration & dosage; Melanoma/metabolism; Metformin/administration & dosage; Mitochondria/metabolism; Oxidative Phosphorylation; Oximes/administration & dosage; Phenformin/administration & dosage; Proto-Oncogene Proteins B-raf/antagonists & inhibitors; Skin Neoplasms/pathology; Sulfonamides/administration & dosage; Vemurafenib

Key words

melanoma; mitochondria; oxidative phosphorylation; phenformin; resistance

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin Neoplasms / Antineoplastic Combined Chemotherapy Protocols / Drug Resistance, Neoplasm / Melanoma Limits: Humans Language: En Journal: Exp Dermatol Journal subject: DERMATOLOGIA Year: 2015 Type: Article Affiliation country: Germany

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