Antagonistic effects of chloroquine on autophagy occurrence potentiate the anticancer effects of everolimus on renal cancer cells.

Grimaldi, A; Santini, D; Zappavigna, S; Lombardi, A; Misso, G; Boccellino, M; Desiderio, V; Vitiello, P P; Di Lorenzo, G; Zoccoli, A; Pantano, F; Caraglia, M

Grimaldi, A; Santini, D; Zappavigna, S; Lombardi, A; Misso, G; Boccellino, M; Desiderio, V; Vitiello, P P; Di Lorenzo, G; Zoccoli, A; Pantano, F; Caraglia, M.

Affiliation

Grimaldi A; a Department of Biochemistry; Biophysics and General Pathology.

Cancer Biol Ther ; 16(4): 567-79, 2015.

Article in En | MEDLINE | ID: mdl-25866016

Subject(s)

Antineoplastic Agents/pharmacology; Autophagy/drug effects; Carcinoma, Renal Cell/drug therapy; Chloroquine/pharmacology; Everolimus/pharmacology; Kidney Neoplasms/drug therapy; Apoptosis/drug effects; Apoptosis Regulatory Proteins/genetics; Beclin-1; Carcinoma, Renal Cell/genetics; Cell Line, Tumor; Cell Survival/drug effects; Drug Synergism; Humans; Kidney Neoplasms/genetics; Lysosomes/drug effects; Membrane Proteins/genetics; Mitochondria/drug effects; Proto-Oncogene Proteins c-bcl-2/genetics; Signal Transduction/drug effects; TOR Serine-Threonine Kinases/genetics

Key words

AVOS, autophagic vacuoles; CLC, chloroquine; FITC, fluorescein isothiocyanate; MDC monodansyl-cadaverine; MFI, mean fluorescence intensity; PI, propidium iodide; RAD, everolimus; VHL, Von Hippel-Lindau; apoptosis; autophagy; chloroquine; everolimus; renal cancer cells

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autophagy / Carcinoma, Renal Cell / Chloroquine / Everolimus / Kidney Neoplasms / Antineoplastic Agents Type of study: Clinical_trials Limits: Humans Language: En Journal: Cancer Biol Ther Journal subject: NEOPLASIAS / TERAPEUTICA Year: 2015 Type: Article

Fulltext

XML

PubMed Links

Search on Google