IAEA-HypoX. A randomized multicenter study of the hypoxic radiosensitizer nimorazole concomitant with accelerated radiotherapy in head and neck squamous cell carcinoma.

Hassan Metwally, Mohamed A; Ali, Rubina; Kuddu, Maire; Shouman, Tarek; Strojan, Primoz; Iqbal, Kashif; Prasad, Rajiv; Grau, Cai; Overgaard, Jens

Hassan Metwally, Mohamed A; Ali, Rubina; Kuddu, Maire; Shouman, Tarek; Strojan, Primoz; Iqbal, Kashif; Prasad, Rajiv; Grau, Cai; Overgaard, Jens.

Affiliation

Hassan Metwally MA; Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark. Electronic address: hassan@oncology.dk.
Ali R; Oncology Department, Nuclear Medicine, Oncology & Radiotherapy Institute, Islamabad, Pakistan.
Kuddu M; Radiation Oncology Center, North Estonia Medical Center, Tallinn, Estonia.
Shouman T; Radiation Oncology Department, National Cancer Institute, Cairo, Egypt.
Strojan P; Department of Radiation Oncology, Institute of Oncology, Ljubljana, Slovenia.
Iqbal K; Oncology Department, Nuclear Medicine, Oncology & Radiotherapy Institute, Islamabad, Pakistan.
Prasad R; Applied Radiation Biology and Radiotherapy Section, International Atomic Energy Agency, Vienna, Austria.
Grau C; Department of Oncology, Aarhus University Hospital, Denmark.
Overgaard J; Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark.

Radiother Oncol ; 116(1): 15-20, 2015 Jul.

Article in En | MEDLINE | ID: mdl-25913070

Subject(s)

Carcinoma, Squamous Cell/radiotherapy; Head and Neck Neoplasms/radiotherapy; Nimorazole/therapeutic use; Radiation-Sensitizing Agents/therapeutic use; Adult; Aged; Carcinoma, Squamous Cell/genetics; Carcinoma, Squamous Cell/pathology; Dose Fractionation, Radiation; Female; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms/genetics; Head and Neck Neoplasms/pathology; Humans; Hypoxia/genetics; Male; Middle Aged; Neoplasm Staging; Patient Compliance; Squamous Cell Carcinoma of Head and Neck

Key words

Accelerated radiotherapy; Clinical trials; HNSCC; Hypoxia; Hypoxic radiosensitization; Nimorazole

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Radiation-Sensitizing Agents / Carcinoma, Squamous Cell / Head and Neck Neoplasms / Nimorazole Type of study: Clinical_trials / Guideline Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Radiother Oncol Year: 2015 Type: Article

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