Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation.
Science
; 246(4937): 1617-20, 1989 Dec 22.
Article
in En
| MEDLINE
| ID: mdl-2595372
ABSTRACT
One action of cyclosporin A thought to be central to many of its immunosuppressive effects is its ability to inhibit the early events of T lymphocyte activation such as lymphokine gene transcription in response to signals initiated at the antigen receptor. Cyclosporin A was found to specifically inhibit the appearance of DNA binding activity of NF-AT, AP-3, and to a lesser extent NF-kappa B, nuclear proteins that appear to be important in the transcriptional activation of the genes for interleukin-2 and its receptor, as well as several other lymphokines. In addition, cyclosporin A abolished the ability of the NF-AT binding site to activate a linked promoter in transfected mitogen-stimulated T lymphocytes and in lymphocytes from transgenic mice. These results indicate that cyclosporin A either directly inhibits the function of nuclear proteins critical to T lymphocyte activation or inhibits the action of a more proximal member of the signal transmission cascade leading from the antigen receptor to the nucleus.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Nuclear Proteins
/
Lymphocyte Activation
/
T-Lymphocytes
/
Gene Expression Regulation
/
Cyclosporins
Limits:
Humans
Language:
En
Journal:
Science
Year:
1989
Type:
Article