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Identification of the inflammasome Nlrp1b as the candidate gene conferring diabetes risk at the Idd4.1 locus in the nonobese diabetic mouse.
Motta, Vinicius N; Markle, Janet G M; Gulban, Omid; Mortin-Toth, Steven; Liao, Kuo-Chien; Mogridge, Jeremy; Steward, Charles A; Danska, Jayne S.
Affiliation
  • Motta VN; Genetics and Genome Biology, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada;
  • Markle JG; Genetics and Genome Biology, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada; Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada;
  • Gulban O; Genetics and Genome Biology, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada;
  • Mortin-Toth S; Genetics and Genome Biology, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada;
  • Liao KC; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada;
  • Mogridge J; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada;
  • Steward CA; Wellcome Trust Sanger Institute, Cambridge CB10 1SA, United Kingdom; and.
  • Danska JS; Genetics and Genome Biology, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada; Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7, Canada jayne.danska@sickkids.ca.
J Immunol ; 194(12): 5663-73, 2015 Jun 15.
Article in En | MEDLINE | ID: mdl-25964492
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Predisposition to Disease / Quantitative Trait Loci / Diabetes Mellitus, Type 1 / Apoptosis Regulatory Proteins / Inflammasomes Type of study: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: J Immunol Year: 2015 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Predisposition to Disease / Quantitative Trait Loci / Diabetes Mellitus, Type 1 / Apoptosis Regulatory Proteins / Inflammasomes Type of study: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: J Immunol Year: 2015 Type: Article