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First-in-human PET quantification study of cerebral α4ß2* nicotinic acetylcholine receptors using the novel specific radioligand (-)-[(18)F]Flubatine.
Sabri, Osama; Becker, Georg-Alexander; Meyer, Philipp M; Hesse, Swen; Wilke, Stephan; Graef, Susanne; Patt, Marianne; Luthardt, Julia; Wagenknecht, Gudrun; Hoepping, Alexander; Smits, René; Franke, Annegret; Sattler, Bernhard; Habermann, Bernd; Neuhaus, Petra; Fischer, Steffen; Tiepolt, Solveig; Deuther-Conrad, Winnie; Barthel, Henryk; Schönknecht, Peter; Brust, Peter.
Affiliation
  • Sabri O; Department of Nuclear Medicine, University of Leipzig, Liebigstraße 18, 04103 Leipzig, Germany; Integrated Research and Treatment Centre (IFB) Adiposity Diseases, University of Leipzig, Philipp-Rosenthal-Straße 27, 04103 Leipzig, Germany. Electronic address: Osama.Sabri@medizin.uni-leipzig.de.
  • Becker GA; Department of Nuclear Medicine, University of Leipzig, Liebigstraße 18, 04103 Leipzig, Germany.
  • Meyer PM; Department of Nuclear Medicine, University of Leipzig, Liebigstraße 18, 04103 Leipzig, Germany.
  • Hesse S; Department of Nuclear Medicine, University of Leipzig, Liebigstraße 18, 04103 Leipzig, Germany; Integrated Research and Treatment Centre (IFB) Adiposity Diseases, University of Leipzig, Philipp-Rosenthal-Straße 27, 04103 Leipzig, Germany.
  • Wilke S; Department of Nuclear Medicine, University of Leipzig, Liebigstraße 18, 04103 Leipzig, Germany.
  • Graef S; Department of Psychiatry, University of Leipzig, Semmelweisstraße 10, 04103 Leipzig, Germany; Max-Planck-Institute for Human Cognitive and Brain Sciences, Stephanstraße 1a, 04103 Leipzig, Germany.
  • Patt M; Department of Nuclear Medicine, University of Leipzig, Liebigstraße 18, 04103 Leipzig, Germany.
  • Luthardt J; Department of Nuclear Medicine, University of Leipzig, Liebigstraße 18, 04103 Leipzig, Germany.
  • Wagenknecht G; Electronic Systems (ZEA-2), Central Institute for Engineering, Electronics and Analytics, Research Centre Juelich, Wilhelm-Johnen-Straße, 52428 Juelich, Germany.
  • Hoepping A; ABX Advanced Biochemical Compounds GmbH, Heinrich-Gläser-Straße 10, 01454 Radeberg, Germany.
  • Smits R; ABX Advanced Biochemical Compounds GmbH, Heinrich-Gläser-Straße 10, 01454 Radeberg, Germany.
  • Franke A; Clinical Trial Centre Leipzig, Härtelstraße 16-18, 04107 Leipzig, Germany.
  • Sattler B; Department of Nuclear Medicine, University of Leipzig, Liebigstraße 18, 04103 Leipzig, Germany.
  • Habermann B; Department of Nuclear Medicine, University of Leipzig, Liebigstraße 18, 04103 Leipzig, Germany.
  • Neuhaus P; Clinical Trial Centre Leipzig, Härtelstraße 16-18, 04107 Leipzig, Germany.
  • Fischer S; Helmholtz-Zentrum Dresden-Rossendorf, Research Site Leipzig, Permoserstraße 15, 04318 Leipzig, Germany.
  • Tiepolt S; Department of Nuclear Medicine, University of Leipzig, Liebigstraße 18, 04103 Leipzig, Germany.
  • Deuther-Conrad W; Helmholtz-Zentrum Dresden-Rossendorf, Research Site Leipzig, Permoserstraße 15, 04318 Leipzig, Germany.
  • Barthel H; Department of Nuclear Medicine, University of Leipzig, Liebigstraße 18, 04103 Leipzig, Germany.
  • Schönknecht P; Department of Psychiatry, University of Leipzig, Semmelweisstraße 10, 04103 Leipzig, Germany.
  • Brust P; Helmholtz-Zentrum Dresden-Rossendorf, Research Site Leipzig, Permoserstraße 15, 04318 Leipzig, Germany.
Neuroimage ; 118: 199-208, 2015 Sep.
Article in En | MEDLINE | ID: mdl-26037057
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzamides / Brain / Receptors, Nicotinic / Bridged Bicyclo Compounds, Heterocyclic / Positron-Emission Tomography Type of study: Prognostic_studies Limits: Aged / Humans / Male / Middle aged Language: En Journal: Neuroimage Journal subject: DIAGNOSTICO POR IMAGEM Year: 2015 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzamides / Brain / Receptors, Nicotinic / Bridged Bicyclo Compounds, Heterocyclic / Positron-Emission Tomography Type of study: Prognostic_studies Limits: Aged / Humans / Male / Middle aged Language: En Journal: Neuroimage Journal subject: DIAGNOSTICO POR IMAGEM Year: 2015 Type: Article