Serotonin and Dopamine Candidate Gene Variants and Alcohol- and Non-Alcohol-Related Aggression.
Alcohol Alcohol
; 50(6): 690-9, 2015 Nov.
Article
in En
| MEDLINE
| ID: mdl-26041607
ABSTRACT
AIMS:
Aggressive and criminal traits have a complex genetic background which interacts with environmental factors. Alcohol intoxication has been related to lower thresholds of aggressive behaviors. In this association study of two independent samples, a number of candidate gene variants (5HT2A T102C, 5-HTTLPR, DRD Ins-141Del, DAT1 VNTR) were related to violent criminal behavior and alcohol-related aggressive traits.METHOD:
Treatment-seeking alcohol-dependent individuals (293 patients and 499 controls from Germany, 180 patients and 402 controls from Poland) underwent a Semi-Structured Assessment for the Genetics of Alcoholism interview which gathered information on alcohol-related violence and criminal behaviors, beside alcohol dependence characteristics.RESULTS:
Patients with a history of violent or non-violent crime were more often male, had an earlier onset of alcoholism, more withdrawal seizures and delirium tremens, and were more likely to have a history of suicide attempts. No significant association between candidate gene variants and criminal behavior was detected. 5HTTLPR variant was related to one characteristic of alcohol-related violence.CONCLUSIONS:
With findings from genome-wide association studies linking aggression-related traits to second messenger systems, further studies are needed to determine the genetic underpinnings of non-alcohol and alcohol-related aggression.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Receptors, Dopamine D1
/
Aggression
/
Receptor, Serotonin, 5-HT2A
/
Alcoholism
/
Dopamine Plasma Membrane Transport Proteins
/
Serotonin Plasma Membrane Transport Proteins
Type of study:
Observational_studies
/
Qualitative_research
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Alcohol Alcohol
Year:
2015
Type:
Article
Affiliation country:
Germany